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Modulation by Sigma-1 Receptor of Morphine Analgesia and Tolerance: Nociceptive Pain, Tactile Allodynia and Grip Strength Deficits During Joint Inflammation
Sigma-1 receptor antagonism increases the effects of morphine on nociceptive pain, even in morphine-tolerant animals. However, it is unknown whether these receptors are able to modulate morphine antinociception and tolerance during inflammatory pain. Here we used a mouse model to test the modulation...
Autores principales: | Montilla-García, Ángeles, Tejada, Miguel Á., Ruiz-Cantero, M. Carmen, Bravo-Caparrós, Inmaculada, Yeste, Sandra, Zamanillo, Daniel, Cobos, Enrique J. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6395397/ https://www.ncbi.nlm.nih.gov/pubmed/30853912 http://dx.doi.org/10.3389/fphar.2019.00136 |
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