Ways Forward for Tolerance-Inducing Cellular Therapies- an AFACTT Perspective

Clinical studies with cellular therapies using tolerance-inducing cells, such as tolerogenic antigen-presenting cells (tolAPC) and regulatory T cells (Treg) for the prevention of transplant rejection and the treatment of autoimmune diseases have been expanding the last decade. In this perspective, w...

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Autores principales: ten Brinke, Anja, Martinez-Llordella, Marc, Cools, Nathalie, Hilkens, Catharien M. U., van Ham, S. Marieke, Sawitzki, Birgit, Geissler, Edward K., Lombardi, Giovanna, Trzonkowski, Piotr, Martinez-Caceres, Eva
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6395407/
https://www.ncbi.nlm.nih.gov/pubmed/30853957
http://dx.doi.org/10.3389/fimmu.2019.00181
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author ten Brinke, Anja
Martinez-Llordella, Marc
Cools, Nathalie
Hilkens, Catharien M. U.
van Ham, S. Marieke
Sawitzki, Birgit
Geissler, Edward K.
Lombardi, Giovanna
Trzonkowski, Piotr
Martinez-Caceres, Eva
author_facet ten Brinke, Anja
Martinez-Llordella, Marc
Cools, Nathalie
Hilkens, Catharien M. U.
van Ham, S. Marieke
Sawitzki, Birgit
Geissler, Edward K.
Lombardi, Giovanna
Trzonkowski, Piotr
Martinez-Caceres, Eva
author_sort ten Brinke, Anja
collection PubMed
description Clinical studies with cellular therapies using tolerance-inducing cells, such as tolerogenic antigen-presenting cells (tolAPC) and regulatory T cells (Treg) for the prevention of transplant rejection and the treatment of autoimmune diseases have been expanding the last decade. In this perspective, we will summarize the current perspectives of the clinical application of both tolAPC and Treg, and will address future directions and the importance of immunomonitoring in clinical studies that will result in progress in the field.
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spelling pubmed-63954072019-03-08 Ways Forward for Tolerance-Inducing Cellular Therapies- an AFACTT Perspective ten Brinke, Anja Martinez-Llordella, Marc Cools, Nathalie Hilkens, Catharien M. U. van Ham, S. Marieke Sawitzki, Birgit Geissler, Edward K. Lombardi, Giovanna Trzonkowski, Piotr Martinez-Caceres, Eva Front Immunol Immunology Clinical studies with cellular therapies using tolerance-inducing cells, such as tolerogenic antigen-presenting cells (tolAPC) and regulatory T cells (Treg) for the prevention of transplant rejection and the treatment of autoimmune diseases have been expanding the last decade. In this perspective, we will summarize the current perspectives of the clinical application of both tolAPC and Treg, and will address future directions and the importance of immunomonitoring in clinical studies that will result in progress in the field. Frontiers Media S.A. 2019-02-22 /pmc/articles/PMC6395407/ /pubmed/30853957 http://dx.doi.org/10.3389/fimmu.2019.00181 Text en Copyright © 2019 ten Brinke, Martinez-Llordella, Cools, Hilkens, van Ham, Sawitzki, Geissler, Lombardi, Trzonkowski and Martinez-Caceres. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
ten Brinke, Anja
Martinez-Llordella, Marc
Cools, Nathalie
Hilkens, Catharien M. U.
van Ham, S. Marieke
Sawitzki, Birgit
Geissler, Edward K.
Lombardi, Giovanna
Trzonkowski, Piotr
Martinez-Caceres, Eva
Ways Forward for Tolerance-Inducing Cellular Therapies- an AFACTT Perspective
title Ways Forward for Tolerance-Inducing Cellular Therapies- an AFACTT Perspective
title_full Ways Forward for Tolerance-Inducing Cellular Therapies- an AFACTT Perspective
title_fullStr Ways Forward for Tolerance-Inducing Cellular Therapies- an AFACTT Perspective
title_full_unstemmed Ways Forward for Tolerance-Inducing Cellular Therapies- an AFACTT Perspective
title_short Ways Forward for Tolerance-Inducing Cellular Therapies- an AFACTT Perspective
title_sort ways forward for tolerance-inducing cellular therapies- an afactt perspective
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6395407/
https://www.ncbi.nlm.nih.gov/pubmed/30853957
http://dx.doi.org/10.3389/fimmu.2019.00181
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