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Controllability affects endocrine response of adolescent male rats to stress as well as impulsivity and behavioral flexibility during adulthood

Exposure to stress during adolescence exerts a long-term impact on behavior and might contribute to the development of several neuropsychiatric disorders. In adults, control over stress has been found to protect from the negative consequences of stress, but the influence of controllability at early...

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Autores principales: Sanchís-Ollé, Maria, Fuentes, Silvia, Úbeda-Contreras, Jesús, Lalanza, Jaume F., Ramos-Prats, Arnau, Armario, Antonio, Nadal, Roser
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6395608/
https://www.ncbi.nlm.nih.gov/pubmed/30816288
http://dx.doi.org/10.1038/s41598-019-40061-3
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author Sanchís-Ollé, Maria
Fuentes, Silvia
Úbeda-Contreras, Jesús
Lalanza, Jaume F.
Ramos-Prats, Arnau
Armario, Antonio
Nadal, Roser
author_facet Sanchís-Ollé, Maria
Fuentes, Silvia
Úbeda-Contreras, Jesús
Lalanza, Jaume F.
Ramos-Prats, Arnau
Armario, Antonio
Nadal, Roser
author_sort Sanchís-Ollé, Maria
collection PubMed
description Exposure to stress during adolescence exerts a long-term impact on behavior and might contribute to the development of several neuropsychiatric disorders. In adults, control over stress has been found to protect from the negative consequences of stress, but the influence of controllability at early ages has not been extensively studied. Here, we evaluated in a rodent model the effects of repeated exposure in adolescent male rats to controllable versus uncontrollable foot-shock stress (CST or UST, respectively). Rats were assigned to three groups: non-stress (stress-naïve), CST (exposed to 8 sessions of a two-way shuttle active avoidance task over a period of 22 days) and UST (receiving the same amount of shocks as CST, regardless of their actual behavior). During adulthood, different cohorts were tested in several tasks evaluating inhibitory control and cognitive flexibility: 5-choice serial reaction time, delay-discounting, gambling test and probabilistic reversal learning. Results showed that the hypothalamic-pituitary-adrenal response to the first shock session was similar in CST and UST animals, but the response to the 8(th) session was lower in CST animals. In adulthood, the UST animals presented impaired motor (but not cognitive) impulsivity and more perseverative behavior. The behavioral effects of UST were associated with increased number of D2 dopamine receptors in dorsomedial striatum, but not in other striatal regions. In summary, UST exposure during adolescence induced long-term impairments in impulsivity and compulsivity, whereas CST had only minor effects. These data support a critical role of stress uncontrollability on the long-lasting consequences of stress, as a risk factor for mental illnesses.
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spelling pubmed-63956082019-03-04 Controllability affects endocrine response of adolescent male rats to stress as well as impulsivity and behavioral flexibility during adulthood Sanchís-Ollé, Maria Fuentes, Silvia Úbeda-Contreras, Jesús Lalanza, Jaume F. Ramos-Prats, Arnau Armario, Antonio Nadal, Roser Sci Rep Article Exposure to stress during adolescence exerts a long-term impact on behavior and might contribute to the development of several neuropsychiatric disorders. In adults, control over stress has been found to protect from the negative consequences of stress, but the influence of controllability at early ages has not been extensively studied. Here, we evaluated in a rodent model the effects of repeated exposure in adolescent male rats to controllable versus uncontrollable foot-shock stress (CST or UST, respectively). Rats were assigned to three groups: non-stress (stress-naïve), CST (exposed to 8 sessions of a two-way shuttle active avoidance task over a period of 22 days) and UST (receiving the same amount of shocks as CST, regardless of their actual behavior). During adulthood, different cohorts were tested in several tasks evaluating inhibitory control and cognitive flexibility: 5-choice serial reaction time, delay-discounting, gambling test and probabilistic reversal learning. Results showed that the hypothalamic-pituitary-adrenal response to the first shock session was similar in CST and UST animals, but the response to the 8(th) session was lower in CST animals. In adulthood, the UST animals presented impaired motor (but not cognitive) impulsivity and more perseverative behavior. The behavioral effects of UST were associated with increased number of D2 dopamine receptors in dorsomedial striatum, but not in other striatal regions. In summary, UST exposure during adolescence induced long-term impairments in impulsivity and compulsivity, whereas CST had only minor effects. These data support a critical role of stress uncontrollability on the long-lasting consequences of stress, as a risk factor for mental illnesses. Nature Publishing Group UK 2019-02-28 /pmc/articles/PMC6395608/ /pubmed/30816288 http://dx.doi.org/10.1038/s41598-019-40061-3 Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Sanchís-Ollé, Maria
Fuentes, Silvia
Úbeda-Contreras, Jesús
Lalanza, Jaume F.
Ramos-Prats, Arnau
Armario, Antonio
Nadal, Roser
Controllability affects endocrine response of adolescent male rats to stress as well as impulsivity and behavioral flexibility during adulthood
title Controllability affects endocrine response of adolescent male rats to stress as well as impulsivity and behavioral flexibility during adulthood
title_full Controllability affects endocrine response of adolescent male rats to stress as well as impulsivity and behavioral flexibility during adulthood
title_fullStr Controllability affects endocrine response of adolescent male rats to stress as well as impulsivity and behavioral flexibility during adulthood
title_full_unstemmed Controllability affects endocrine response of adolescent male rats to stress as well as impulsivity and behavioral flexibility during adulthood
title_short Controllability affects endocrine response of adolescent male rats to stress as well as impulsivity and behavioral flexibility during adulthood
title_sort controllability affects endocrine response of adolescent male rats to stress as well as impulsivity and behavioral flexibility during adulthood
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6395608/
https://www.ncbi.nlm.nih.gov/pubmed/30816288
http://dx.doi.org/10.1038/s41598-019-40061-3
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