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Endothelin neurotransmitter signalling controls zebrafish social behaviour
The formation of social groups is an adaptive behaviour that can provide protection from predators, improve foraging and facilitate social learning. However, the costs of proximity can include competition for resources, aggression and kleptoparasitism meaning that the decision whether to interact re...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6395658/ https://www.ncbi.nlm.nih.gov/pubmed/30816294 http://dx.doi.org/10.1038/s41598-019-39907-7 |
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author | Carreño Gutiérrez, Héctor Colanesi, Sarah Cooper, Ben Reichmann, Florian Young, Andrew M. J. Kelsh, Robert N. Norton, William H. J. |
author_facet | Carreño Gutiérrez, Héctor Colanesi, Sarah Cooper, Ben Reichmann, Florian Young, Andrew M. J. Kelsh, Robert N. Norton, William H. J. |
author_sort | Carreño Gutiérrez, Héctor |
collection | PubMed |
description | The formation of social groups is an adaptive behaviour that can provide protection from predators, improve foraging and facilitate social learning. However, the costs of proximity can include competition for resources, aggression and kleptoparasitism meaning that the decision whether to interact represents a trade-off. Here we show that zebrafish harbouring a mutation in endothelin receptor aa (ednraa) form less cohesive shoals than wild-types. ednraa(−/−) mutants exhibit heightened aggression and decreased whole-body cortisol levels suggesting that they are dominant. These behavioural changes correlate with a reduction of parvocellular arginine vasopressin (AVP)-positive neurons in the preoptic area, an increase in the size of magnocellular AVP neurons and a higher concentration of 5-HT and dopamine in the brain. Manipulation of AVP or 5-HT signalling can rescue the shoaling phenotype of ednraa(−/−) providing an insight into how the brain controls social interactions. |
format | Online Article Text |
id | pubmed-6395658 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-63956582019-03-04 Endothelin neurotransmitter signalling controls zebrafish social behaviour Carreño Gutiérrez, Héctor Colanesi, Sarah Cooper, Ben Reichmann, Florian Young, Andrew M. J. Kelsh, Robert N. Norton, William H. J. Sci Rep Article The formation of social groups is an adaptive behaviour that can provide protection from predators, improve foraging and facilitate social learning. However, the costs of proximity can include competition for resources, aggression and kleptoparasitism meaning that the decision whether to interact represents a trade-off. Here we show that zebrafish harbouring a mutation in endothelin receptor aa (ednraa) form less cohesive shoals than wild-types. ednraa(−/−) mutants exhibit heightened aggression and decreased whole-body cortisol levels suggesting that they are dominant. These behavioural changes correlate with a reduction of parvocellular arginine vasopressin (AVP)-positive neurons in the preoptic area, an increase in the size of magnocellular AVP neurons and a higher concentration of 5-HT and dopamine in the brain. Manipulation of AVP or 5-HT signalling can rescue the shoaling phenotype of ednraa(−/−) providing an insight into how the brain controls social interactions. Nature Publishing Group UK 2019-02-28 /pmc/articles/PMC6395658/ /pubmed/30816294 http://dx.doi.org/10.1038/s41598-019-39907-7 Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Carreño Gutiérrez, Héctor Colanesi, Sarah Cooper, Ben Reichmann, Florian Young, Andrew M. J. Kelsh, Robert N. Norton, William H. J. Endothelin neurotransmitter signalling controls zebrafish social behaviour |
title | Endothelin neurotransmitter signalling controls zebrafish social behaviour |
title_full | Endothelin neurotransmitter signalling controls zebrafish social behaviour |
title_fullStr | Endothelin neurotransmitter signalling controls zebrafish social behaviour |
title_full_unstemmed | Endothelin neurotransmitter signalling controls zebrafish social behaviour |
title_short | Endothelin neurotransmitter signalling controls zebrafish social behaviour |
title_sort | endothelin neurotransmitter signalling controls zebrafish social behaviour |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6395658/ https://www.ncbi.nlm.nih.gov/pubmed/30816294 http://dx.doi.org/10.1038/s41598-019-39907-7 |
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