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Endothelin neurotransmitter signalling controls zebrafish social behaviour

The formation of social groups is an adaptive behaviour that can provide protection from predators, improve foraging and facilitate social learning. However, the costs of proximity can include competition for resources, aggression and kleptoparasitism meaning that the decision whether to interact re...

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Autores principales: Carreño Gutiérrez, Héctor, Colanesi, Sarah, Cooper, Ben, Reichmann, Florian, Young, Andrew M. J., Kelsh, Robert N., Norton, William H. J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6395658/
https://www.ncbi.nlm.nih.gov/pubmed/30816294
http://dx.doi.org/10.1038/s41598-019-39907-7
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author Carreño Gutiérrez, Héctor
Colanesi, Sarah
Cooper, Ben
Reichmann, Florian
Young, Andrew M. J.
Kelsh, Robert N.
Norton, William H. J.
author_facet Carreño Gutiérrez, Héctor
Colanesi, Sarah
Cooper, Ben
Reichmann, Florian
Young, Andrew M. J.
Kelsh, Robert N.
Norton, William H. J.
author_sort Carreño Gutiérrez, Héctor
collection PubMed
description The formation of social groups is an adaptive behaviour that can provide protection from predators, improve foraging and facilitate social learning. However, the costs of proximity can include competition for resources, aggression and kleptoparasitism meaning that the decision whether to interact represents a trade-off. Here we show that zebrafish harbouring a mutation in endothelin receptor aa (ednraa) form less cohesive shoals than wild-types. ednraa(−/−) mutants exhibit heightened aggression and decreased whole-body cortisol levels suggesting that they are dominant. These behavioural changes correlate with a reduction of parvocellular arginine vasopressin (AVP)-positive neurons in the preoptic area, an increase in the size of magnocellular AVP neurons and a higher concentration of 5-HT and dopamine in the brain. Manipulation of AVP or 5-HT signalling can rescue the shoaling phenotype of ednraa(−/−) providing an insight into how the brain controls social interactions.
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spelling pubmed-63956582019-03-04 Endothelin neurotransmitter signalling controls zebrafish social behaviour Carreño Gutiérrez, Héctor Colanesi, Sarah Cooper, Ben Reichmann, Florian Young, Andrew M. J. Kelsh, Robert N. Norton, William H. J. Sci Rep Article The formation of social groups is an adaptive behaviour that can provide protection from predators, improve foraging and facilitate social learning. However, the costs of proximity can include competition for resources, aggression and kleptoparasitism meaning that the decision whether to interact represents a trade-off. Here we show that zebrafish harbouring a mutation in endothelin receptor aa (ednraa) form less cohesive shoals than wild-types. ednraa(−/−) mutants exhibit heightened aggression and decreased whole-body cortisol levels suggesting that they are dominant. These behavioural changes correlate with a reduction of parvocellular arginine vasopressin (AVP)-positive neurons in the preoptic area, an increase in the size of magnocellular AVP neurons and a higher concentration of 5-HT and dopamine in the brain. Manipulation of AVP or 5-HT signalling can rescue the shoaling phenotype of ednraa(−/−) providing an insight into how the brain controls social interactions. Nature Publishing Group UK 2019-02-28 /pmc/articles/PMC6395658/ /pubmed/30816294 http://dx.doi.org/10.1038/s41598-019-39907-7 Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Carreño Gutiérrez, Héctor
Colanesi, Sarah
Cooper, Ben
Reichmann, Florian
Young, Andrew M. J.
Kelsh, Robert N.
Norton, William H. J.
Endothelin neurotransmitter signalling controls zebrafish social behaviour
title Endothelin neurotransmitter signalling controls zebrafish social behaviour
title_full Endothelin neurotransmitter signalling controls zebrafish social behaviour
title_fullStr Endothelin neurotransmitter signalling controls zebrafish social behaviour
title_full_unstemmed Endothelin neurotransmitter signalling controls zebrafish social behaviour
title_short Endothelin neurotransmitter signalling controls zebrafish social behaviour
title_sort endothelin neurotransmitter signalling controls zebrafish social behaviour
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6395658/
https://www.ncbi.nlm.nih.gov/pubmed/30816294
http://dx.doi.org/10.1038/s41598-019-39907-7
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