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Probing the Behaviour of Cas1-Cas2 upon Protospacer Binding in CRISPR-Cas Systems using Molecular Dynamics Simulations

Adaptation in CRISPR-Cas systems enables the generation of an immunological memory to defend against invading viruses. This process is driven by foreign DNA spacer (termed protospacer) selection and integration mediated by Cas1-Cas2 protein. Recently, different states of Cas1-Cas2, in its free form...

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Detalles Bibliográficos
Autores principales:	Wan, Hua, Li, Jianming, Chang, Shan, Lin, Shuoxin, Tian, Yuanxin, Tian, Xuhong, Wang, Meihua, Hu, Jianping
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6395717/ https://www.ncbi.nlm.nih.gov/pubmed/30816277 http://dx.doi.org/10.1038/s41598-019-39616-1

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