Differential methylation of the type 2 diabetes susceptibility locus KCNQ1 is associated with insulin sensitivity and is predicted by CpG site specific genetic variation

AIMS: Epigenetic mechanisms regulate gene expression and may influence the pathogenesis of type 2 diabetes through the loss of insulin sensitivity. The aims of this study were to measure variation in DNA methylation at the type 2 diabetes locus KCNQ1 and assess its relationship with metabolic measur...

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Detalles Bibliográficos
Autores principales: Shah, Ushma J., Xie, Weijia, Flyvbjerg, Allan, Nolan, John J., Højlund, Kurt, Walker, Mark, Relton, Caroline L., Elliott, Hannah R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Scientific Publishers 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6395844/
https://www.ncbi.nlm.nih.gov/pubmed/30641161
http://dx.doi.org/10.1016/j.diabres.2019.01.008

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