Faster, higher, stronger: timely and robust cell fate/identity commitment in stem cell lineages

Precise specification of cell fate or identity within stem cell lineages is critical for ensuring correct stem cell lineage progression and tissue homeostasis. Failure to specify cell fate or identity in a timely and robust manner can result in developmental abnormalities and diseases such as cancer...

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Detalles Bibliográficos
Autores principales: Liu, Kun, Xu, Ke, Song, Yan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6395883/
https://www.ncbi.nlm.nih.gov/pubmed/30958098
http://dx.doi.org/10.1098/rsob.180243
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author Liu, Kun
Xu, Ke
Song, Yan
author_facet Liu, Kun
Xu, Ke
Song, Yan
author_sort Liu, Kun
collection PubMed
description Precise specification of cell fate or identity within stem cell lineages is critical for ensuring correct stem cell lineage progression and tissue homeostasis. Failure to specify cell fate or identity in a timely and robust manner can result in developmental abnormalities and diseases such as cancer. However, the molecular basis of timely cell fate/identity specification is only beginning to be understood. In this review, we discuss key regulatory strategies employed in cell fate specification and highlight recent results revealing how timely and robust cell fate/identity commitment is achieved through transcriptional control.
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spelling pubmed-63958832019-03-05 Faster, higher, stronger: timely and robust cell fate/identity commitment in stem cell lineages Liu, Kun Xu, Ke Song, Yan Open Biol Review Precise specification of cell fate or identity within stem cell lineages is critical for ensuring correct stem cell lineage progression and tissue homeostasis. Failure to specify cell fate or identity in a timely and robust manner can result in developmental abnormalities and diseases such as cancer. However, the molecular basis of timely cell fate/identity specification is only beginning to be understood. In this review, we discuss key regulatory strategies employed in cell fate specification and highlight recent results revealing how timely and robust cell fate/identity commitment is achieved through transcriptional control. The Royal Society 2019-02-27 /pmc/articles/PMC6395883/ /pubmed/30958098 http://dx.doi.org/10.1098/rsob.180243 Text en © 2019 The Authors. http://creativecommons.org/licenses/by/4.0/ Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited.
spellingShingle Review
Liu, Kun
Xu, Ke
Song, Yan
Faster, higher, stronger: timely and robust cell fate/identity commitment in stem cell lineages
title Faster, higher, stronger: timely and robust cell fate/identity commitment in stem cell lineages
title_full Faster, higher, stronger: timely and robust cell fate/identity commitment in stem cell lineages
title_fullStr Faster, higher, stronger: timely and robust cell fate/identity commitment in stem cell lineages
title_full_unstemmed Faster, higher, stronger: timely and robust cell fate/identity commitment in stem cell lineages
title_short Faster, higher, stronger: timely and robust cell fate/identity commitment in stem cell lineages
title_sort faster, higher, stronger: timely and robust cell fate/identity commitment in stem cell lineages
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6395883/
https://www.ncbi.nlm.nih.gov/pubmed/30958098
http://dx.doi.org/10.1098/rsob.180243
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AT songyan fasterhigherstrongertimelyandrobustcellfateidentitycommitmentinstemcelllineages

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