Emergence of a Multidrug-Resistant Hypervirulent Klebsiella pneumoniae Sequence Type 23 Strain with a Rare bla(CTX-M-24)-Harboring Virulence Plasmid

Here, we report a multidrug-resistant hypervirulent Klebsiella pneumoniae (MDR-HvKP) strain of sequence type 23 (ST23) with a rare hybrid plasmid harboring virulence genes and bla(CTX-M-24), and we analyze the genetic basis for relationship between genotypes and MDR-hypervirulence phenotypes. Furthe...

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Detalles Bibliográficos
Autores principales: Shen, Dingxia, Ma, Guannan, Li, Cuidan, Jia, Xinmiao, Qin, Chuan, Yang, Tingting, Wang, Lifeng, Jiang, Xiaoyuan, Ding, Nan, Zhang, Xiuli, Yue, Liya, Yin, Zhe, Zeng, Lijun, Zhao, Yongliang, Zhou, Dongsheng, Chen, Fei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2019
Materias:
Mechanisms of Resistance
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6395898/
https://www.ncbi.nlm.nih.gov/pubmed/30602516
http://dx.doi.org/10.1128/AAC.02273-18
Descripción
Sumario:Here, we report a multidrug-resistant hypervirulent Klebsiella pneumoniae (MDR-HvKP) strain of sequence type 23 (ST23) with a rare hybrid plasmid harboring virulence genes and bla(CTX-M-24), and we analyze the genetic basis for relationship between genotypes and MDR-hypervirulence phenotypes. Further analysis indicates that the hybrid plasmid is formed by IS903D-mediated intermolecular transposition of the bla(CTX-M-24) gene into the virulence plasmid. The emergence of MDR-HvKP strains, especially those carrying drug-resistant virulent plasmids, poses unprecedented threats/challenges to public health. This is a dangerous trend and should be closely monitored.

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