Double deletion of PINK1 and Parkin impairs hepatic mitophagy and exacerbates acetaminophen-induced liver injury in mice

Mitochondria damage plays a critical role in acetaminophen (APAP)-induced necrosis and liver injury. Cells can adapt and protect themselves by removing damaged mitochondria via mitophagy. PINK1-Parkin pathway is one of the major pathways that regulate mitophagy but its role in APAP-induced liver inj...

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Detalles Bibliográficos
Autores principales: Wang, Hua, Ni, Hong-Min, Chao, Xiaojuan, Ma, Xiaowen, Rodriguez, Yssa Ann, Chavan, Hemantkumar, Wang, Shaogui, Krishnamurthy, Partha, Dobrowsky, Rick, Xu, De-Xiang, Jaeschke, Hartmut, Ding, Wen-Xing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6395945/
https://www.ncbi.nlm.nih.gov/pubmed/30818124
http://dx.doi.org/10.1016/j.redox.2019.101148

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