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aPKCι promotes gallbladder cancer tumorigenesis and gemcitabine resistance by competing with Nrf2 for binding to Keap1

Gallbladder cancer (GBC) is a highly malignant bile duct cancer with poor prognosis characterized by its insensitivity to chemotherapy. Emerging evidence indicates that cytoprotective antioxidation is involved in drug resistance of various cancers; however, the underlying molecular mechanisms remain...

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Detalles Bibliográficos
Autores principales:	Tian, Li, Lu, Yun, Yang, Tao, Deng, Zhengdong, Xu, Lei, Yao, Wei, Ma, Chaoqun, Li, Xiangyu, Zhang, Jian, Liu, Yan, Wang, Jianming
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2019
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6395946/ https://www.ncbi.nlm.nih.gov/pubmed/30822690 http://dx.doi.org/10.1016/j.redox.2019.101149

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