Cargando…

Systemic inactivation of hypoxia-inducible factor prolyl 4-hydroxylase 2 in mice protects from alcohol-induced fatty liver disease

Alcoholic fatty liver disease (AFLD) is a growing health problem for which no targeted therapy is available. We set out to study whether systemic inactivation of the main hypoxia-inducible factor prolyl 4-hydroxylase, HIF-P4H-2 (PHD2/EglN1), whose inactivation has been associated with protection aga...

Descripción completa

Detalles Bibliográficos
Autores principales:	Laitakari, Anna, Ollonen, Teemu, Kietzmann, Thomas, Walkinshaw, Gail, Mennerich, Daniela, Izzi, Valerio, Haapasaari, Kirsi-Maria, Myllyharju, Johanna, Serpi, Raisa, Dimova, Elitsa Y., Koivunen, Peppi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2019
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396018/ https://www.ncbi.nlm.nih.gov/pubmed/30802717 http://dx.doi.org/10.1016/j.redox.2019.101145

Ejemplares similares

HIF-P4H-2 inhibition enhances intestinal fructose metabolism and induces thermogenesis protecting against NAFLD
por: Laitakari, Anna, et al.
Publicado: (2020)

Activation of the hypoxia response protects mice from amyloid-β accumulation
por: Ollonen, Teemu, et al.
Publicado: (2022)

Contribution of HIF-P4H isoenzyme inhibition to metabolism indicates major beneficial effects being conveyed by HIF-P4H-2 antagonism
por: Tapio, Joona, et al.
Publicado: (2022)

Inactivation of mouse transmembrane prolyl 4-hydroxylase increases blood brain barrier permeability and ischemia-induced cerebral neuroinflammation
por: Byts, Nadiya, et al.
Publicado: (2022)

Structure of transmembrane prolyl 4-hydroxylase reveals unique organization of EF and dioxygenase domains
por: Myllykoski, Matti, et al.
Publicado: (2020)

Transmembrane Prolyl 4-Hydroxylase is a Novel Regulator of Calcium Signaling in Astrocytes
por: Byts, Nadiya, et al.
Publicado: (2021)

Expression and Roles of Individual HIF Prolyl 4-Hydroxylase Isoenzymes in the Regulation of the Hypoxia Response Pathway along the Murine Gastrointestinal Epithelium
por: Dengler, Franziska, et al.
Publicado: (2021)

Hypoxia causes reductions in birth weight by altering maternal glucose and lipid metabolism
por: Määttä, Jenni, et al.
Publicado: (2018)

Author Correction: Hypoxia causes reductions in birth weight by altering maternal glucose and lipid metabolism
por: Määttä, Jenni, et al.
Publicado: (2020)

Prolyl hydroxylase domain 2 reduction enhances skeletal muscle tissue regeneration after soft tissue trauma in mice
por: Settelmeier, Stephan, et al.
Publicado: (2020)

Hypoxia-Inducible Factors (HIFs) and Phosphorylation: Impact on Stability, Localization, and Transactivity
por: Kietzmann, Thomas, et al.
Publicado: (2016)

Direct phosphorylation events involved in HIF-α regulation: the role of GSK-3β
por: Mennerich, Daniela, et al.
Publicado: (2014)

Hypoxia-inducible factor prolyl-4-hydroxylase-1 is a convergent point in the reciprocal negative regulation of NF-κB and p53 signaling pathways
por: Ullah, Karim, et al.
Publicado: (2017)

Update on hypoxia-inducible factors and hydroxylases in oxygen regulatory pathways: from physiology to therapeutics
por: Ratcliffe, Peter, et al.
Publicado: (2017)

Sandwich ELISA for quantitative detection of human collagen prolyl 4-hydroxylase
por: Osmekhina, Ekaterina, et al.
Publicado: (2010)

The prognostic significance and value of cyclin D1, CDK4 and p16 in human breast cancer
por: Peurala, Emmi, et al.
Publicado: (2013)

Hypoxia ameliorates maternal diet‐induced insulin resistance during pregnancy while having a detrimental effect on the placenta
por: Sissala, Niina, et al.
Publicado: (2022)

Differential transcriptional regulation of hypoxia-inducible factor-1α by arsenite under normoxia and hypoxia: involvement of Nrf2
por: al Taleb, Zukaa, et al.
Publicado: (2016)

Post-ischemic inactivation of HIF prolyl hydroxylases in endothelium promotes maladaptive kidney repair by inducing glycolysis
por: Tiwari, Ratnakar, et al.
Publicado: (2023)

Reduced Bone Mass in Collagen Prolyl 4‐Hydroxylase P4ha1 (+/−); P4ha2 (−/−) Compound Mutant Mice
por: Tolonen, Jussi‐Pekka, et al.
Publicado: (2022)

Inhibition of HIF prolyl-4-hydroxylases by FG-4497 Reduces Brain Tissue Injury and Edema Formation during Ischemic Stroke
por: Reischl, Stefan, et al.
Publicado: (2014)

The Circadian Clock Protein CRY1 Is a Negative Regulator of HIF-1α
por: Dimova, Elitsa Y., et al.
Publicado: (2019)

Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitors and Iron Metabolism
por: Ogawa, Chie, et al.
Publicado: (2023)

Hypoxia inducible factor prolyl hydroxylases in inflammatory bowel disease
por: Lun, Jie, et al.
Publicado: (2023)

Deletion of hypoxia-inducible factor prolyl 4-hydroxylase 2 in FoxD1-lineage mesenchymal cells leads to congenital truncal alopecia
por: Rosendahl, Ann-Helen, et al.
Publicado: (2022)

Lack of activity of recombinant HIF prolyl hydroxylases (PHDs) on reported non-HIF substrates
por: Cockman, Matthew E, et al.
Publicado: (2019)

Prolyl hydroxylase 2 inactivation enhances glycogen storage and promotes excessive neutrophilic responses
por: Sadiku, Pranvera, et al.
Publicado: (2017)

Hypoxia-inducible factor prolyl hydroxylase 2 (PHD2) is a direct regulator of epidermal growth factor receptor (EGFR) signaling in breast cancer
por: Kozlova, Nina, et al.
Publicado: (2016)

Hypoxia-inducible factor prolyl hydroxylase inhibitors in kidney transplant recipients
por: Ogata, Masatomo, et al.
Publicado: (2022)

Bibliometric analysis of hypoxia inducible factor prolyl hydroxylase inhibitor in anemia
por: Zheng, Li, et al.
Publicado: (2022)

α-Ketoglutarate Inhibits Thrombosis and Inflammation by Prolyl Hydroxylase-2 Mediated Inactivation of Phospho-Akt
por: Shrimali, Nishith M, et al.
Publicado: (2021)

Loss of USF2 promotes proliferation, migration and mitophagy in a redox-dependent manner
por: Chi, Tabughang Franklin, et al.
Publicado: (2020)

Complement C1q is hydroxylated by collagen prolyl 4 hydroxylase and is sensitive to off-target inhibition by prolyl hydroxylase domain inhibitors that stabilize hypoxia-inducible factor
por: Kiriakidis, Serafim, et al.
Publicado: (2017)

Involvement of Prolyl Hydroxylase Domain Protein in the Rosiglitazone-Induced Suppression of Osteoblast Differentiation
por: Kang, Ju-Hee, et al.
Publicado: (2015)

Updates on Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitors in the Treatment of Renal Anemia
por: Li, Jing, et al.
Publicado: (2022)

The role of HIF prolyl hydroxylases in tumour growth
por: Jokilehto, Terhi, et al.
Publicado: (2010)

Function and expression of prolyl hydroxylase 3 in cancers
por: Liu, Qiu-long, et al.
Publicado: (2013)

Loss of Endothelial Hypoxia Inducible Factor‐Prolyl Hydroxylase 2 Induces Cardiac Hypertrophy and Fibrosis
por: Dai, Zhiyu, et al.
Publicado: (2021)

Recent Advances in Developing Inhibitors for Hypoxia-Inducible Factor Prolyl Hydroxylases and Their Therapeutic Implications
por: Kim, So Yeon, et al.
Publicado: (2015)

Use of cyclic peptides to induce crystallization: case study with prolyl hydroxylase domain 2
por: Chowdhury, Rasheduzzaman, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_bdt76vjr86m21hbnbmn97695ku