Cargando…
Mathematical modeling of bone in-growth into undegradable porous periodic scaffolds under mechanical stimulus
Undegradable scaffolds, as a key element in bone tissue engineering, prevail in the present clinical applications, and the bone in-growth into such scaffolds under mechanical stimulus is an important issue to evaluate the bone-repair effect. This work aims to develop a mathematical framework to inve...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396048/ https://www.ncbi.nlm.nih.gov/pubmed/30834099 http://dx.doi.org/10.1177/2041731419827167 |
_version_ | 1783399193224675328 |
---|---|
author | Liu, Lingze Shi, Quan Chen, Qiang Li, Zhiyong |
author_facet | Liu, Lingze Shi, Quan Chen, Qiang Li, Zhiyong |
author_sort | Liu, Lingze |
collection | PubMed |
description | Undegradable scaffolds, as a key element in bone tissue engineering, prevail in the present clinical applications, and the bone in-growth into such scaffolds under mechanical stimulus is an important issue to evaluate the bone-repair effect. This work aims to develop a mathematical framework to investigate the effect of mechanical stimulus on the bone in-growth into undegradable scaffolds. First, the osteoclast and osteoblast activities were coupled by their autocrine and paracrine effects. Second, the mechanical stimulus was empirically incorporated into the coupling cell activities on the basis of experimental observations. Third, the effect of mechanical stimulus including intensity and duration on the bone in-growth process was numerically studied; moreover, the homeostasis of scaffold–bone system under the mechanical stimulus was also treated. The results showed that the numbers of osteoblasts and osteoclasts in the scaffold–bone system tended to constants representing the system homeostasis. Both the mechanical intensity and duration optimized the final bone formation. The numerical results of the bone formation were comparable to the experimental results in rats. The findings from this modeling study could be used to explain many physiological phenomena and clinical observations. The developed model integrates both cell and tissue scales, which can be used as a platform to investigate bone remodeling under mechanical stimulus. |
format | Online Article Text |
id | pubmed-6396048 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-63960482019-03-04 Mathematical modeling of bone in-growth into undegradable porous periodic scaffolds under mechanical stimulus Liu, Lingze Shi, Quan Chen, Qiang Li, Zhiyong J Tissue Eng The Role and Contributions of Mathematical Modelling in Tissue Engineering and Regenerative Medicine Undegradable scaffolds, as a key element in bone tissue engineering, prevail in the present clinical applications, and the bone in-growth into such scaffolds under mechanical stimulus is an important issue to evaluate the bone-repair effect. This work aims to develop a mathematical framework to investigate the effect of mechanical stimulus on the bone in-growth into undegradable scaffolds. First, the osteoclast and osteoblast activities were coupled by their autocrine and paracrine effects. Second, the mechanical stimulus was empirically incorporated into the coupling cell activities on the basis of experimental observations. Third, the effect of mechanical stimulus including intensity and duration on the bone in-growth process was numerically studied; moreover, the homeostasis of scaffold–bone system under the mechanical stimulus was also treated. The results showed that the numbers of osteoblasts and osteoclasts in the scaffold–bone system tended to constants representing the system homeostasis. Both the mechanical intensity and duration optimized the final bone formation. The numerical results of the bone formation were comparable to the experimental results in rats. The findings from this modeling study could be used to explain many physiological phenomena and clinical observations. The developed model integrates both cell and tissue scales, which can be used as a platform to investigate bone remodeling under mechanical stimulus. SAGE Publications 2019-02-28 /pmc/articles/PMC6396048/ /pubmed/30834099 http://dx.doi.org/10.1177/2041731419827167 Text en © The Author(s) 2019 http://www.creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | The Role and Contributions of Mathematical Modelling in Tissue Engineering and Regenerative Medicine Liu, Lingze Shi, Quan Chen, Qiang Li, Zhiyong Mathematical modeling of bone in-growth into undegradable porous periodic scaffolds under mechanical stimulus |
title | Mathematical modeling of bone in-growth into undegradable porous periodic scaffolds under mechanical stimulus |
title_full | Mathematical modeling of bone in-growth into undegradable porous periodic scaffolds under mechanical stimulus |
title_fullStr | Mathematical modeling of bone in-growth into undegradable porous periodic scaffolds under mechanical stimulus |
title_full_unstemmed | Mathematical modeling of bone in-growth into undegradable porous periodic scaffolds under mechanical stimulus |
title_short | Mathematical modeling of bone in-growth into undegradable porous periodic scaffolds under mechanical stimulus |
title_sort | mathematical modeling of bone in-growth into undegradable porous periodic scaffolds under mechanical stimulus |
topic | The Role and Contributions of Mathematical Modelling in Tissue Engineering and Regenerative Medicine |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396048/ https://www.ncbi.nlm.nih.gov/pubmed/30834099 http://dx.doi.org/10.1177/2041731419827167 |
work_keys_str_mv | AT liulingze mathematicalmodelingofboneingrowthintoundegradableporousperiodicscaffoldsundermechanicalstimulus AT shiquan mathematicalmodelingofboneingrowthintoundegradableporousperiodicscaffoldsundermechanicalstimulus AT chenqiang mathematicalmodelingofboneingrowthintoundegradableporousperiodicscaffoldsundermechanicalstimulus AT lizhiyong mathematicalmodelingofboneingrowthintoundegradableporousperiodicscaffoldsundermechanicalstimulus |