IFITM proteins drive type 2 T helper cell differentiation and exacerbate allergic airway inflammation

The interferon‐inducible transmembrane (Ifitm/Fragilis) genes encode homologous proteins that are induced by IFNs. Here, we show that IFITM proteins regulate murine CD4(+) Th cell differentiation. Ifitm2 and Ifitm3 are expressed in wild‐type (WT) CD4(+) T cells. On activation, Ifitm3 was downregulat...

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Detalles Bibliográficos
Autores principales: Yánez, Diana C., Sahni, Hemant, Ross, Susan, Solanki, Anisha, Lau, Ching‐In, Papaioannou, Eleftheria, Barbarulo, Alessandro, Powell, Rebecca, Lange, Ulrike C., Adams, David J., Barenco, Martino, Ono, Masahiro, D'Acquisto, Fulvio, Furmanski, Anna L., Crompton, Tessa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Adaptive immunity
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396086/
https://www.ncbi.nlm.nih.gov/pubmed/30365177
http://dx.doi.org/10.1002/eji.201847692

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396086/
https://www.ncbi.nlm.nih.gov/pubmed/30365177
http://dx.doi.org/10.1002/eji.201847692

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