Discovery of High-Affinity Noncovalent Allosteric KRAS Inhibitors That Disrupt Effector Binding

[Image: see text] Approximately 15% of all human tumors harbor mutant KRAS, a membrane-associated small GTPase and notorious oncogene. Mutations that render KRAS constitutively active will lead to uncontrolled cell growth and cancer. However, despite aggressive efforts in recent years, there are no...

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Detalles Bibliográficos
Autores principales: McCarthy, Michael J., Pagba, Cynthia V., Prakash, Priyanka, Naji, Ali K., van der Hoeven, Dharini, Liang, Hong, Gupta, Amit K., Zhou, Yong, Cho, Kwang-Jin, Hancock, John F., Gorfe, Alemayehu A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2019
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396121/
https://www.ncbi.nlm.nih.gov/pubmed/30842983
http://dx.doi.org/10.1021/acsomega.8b03308

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