Genetics, diagnosis and treatment of Lynch syndrome: Old lessons and current challenges

Lynch syndrome (LS) is an autosomal dominant genetic disorder associated with germline mutations in DNA mismatch repair (MMR) genes. The carriers of pathogenic mutations in these genes have an increased risk of developing a colorectal cancer and/or LS-associated cancer. The LS-associated cancer type...

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Detalles Bibliográficos
Autores principales: Duraturo, Francesca, Liccardo, Raffaella, De Rosa, Marina, Izzo, Paola
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396136/
https://www.ncbi.nlm.nih.gov/pubmed/30867733
http://dx.doi.org/10.3892/ol.2019.9945

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