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Therapeutic Protein PEPylation: The Helix of Nonfouling Synthetic Polypeptides Minimizes Antidrug Antibody Generation

[Image: see text] Polymer conjugation is a clinically proven approach to generate long acting protein drugs with decreased immune responses. Although poly(ethylene glycol) (PEG) is one of the most commonly used conjugation partners due to its unstructured conformation, its therapeutic application is...

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Detalles Bibliográficos
Autores principales:	Hou, Yingqin, Zhou, Yu, Wang, Hao, Sun, Jialing, Wang, Ruijue, Sheng, Kai, Yuan, Jingsong, Hu, Yali, Chao, Yu, Liu, Zhuang, Lu, Hua
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2019
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396190/ https://www.ncbi.nlm.nih.gov/pubmed/30834311 http://dx.doi.org/10.1021/acscentsci.8b00548

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