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N-myristoyltransferase deficiency impairs AMPK activation and promotes synovial tissue inflammation

N-myristoyltransferase (NMT) attaches the fatty acid myristate to the N-terminal glycine of proteins to sort them into soluble and membrane-bound fractions. Function of the energy-sensing AMP-activated protein kinase (AMPK) is myristoylation-dependent. In rheumatoid arthritis (RA), pathogenic T cell...

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Detalles Bibliográficos
Autores principales:	Wen, Zhenke, Jin, Ke, Shen, Yi, Yang, Zhen, Li, Yinyin, Wu, Bowen, Tian, Lu, Shoor, Stanford, Roche, Niall E., Goronzy, Jorg J., Weyand, Cornelia M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396296/ https://www.ncbi.nlm.nih.gov/pubmed/30718913 http://dx.doi.org/10.1038/s41590-018-0296-7

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