Duplication of ALK F1245 missense mutation due to acquired uniparental disomy associated with aggressive progression in a patient with relapsed neuroblastoma

Recent genome-wide analysis of neuroblastoma (NBL) revealed amplification and heterozygous mutation of anaplastic lymphoma kinase (ALK) are responsible for oncogenicity, frequently observed during relapses. A 3-year-old girl with relapsed high-risk NBL had a heterozygous ALK F1245L mutation at diagn...

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Detalles Bibliográficos
Autores principales: Kimura, Shunsuke, Hasegawa, Daisuke, Yoshimoto, Yuri, Seki, Masafumi, Daida, Atsuro, Sekiguchi, Masahiro, Hirabayashi, Shinsuke, Hosoya, Yosuke, Kobayashi, Masao, Miyano, Satoru, Ogawa, Seishi, Takita, Junko, Manabe, Atsushi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2019
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396392/
https://www.ncbi.nlm.nih.gov/pubmed/30867766
http://dx.doi.org/10.3892/ol.2019.9985

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