Large-scale discovery of mouse transgenic integration sites reveals frequent structural variation and insertional mutagenesis

Transgenesis has been a mainstay of mouse genetics for over 30 yr, providing numerous models of human disease and critical genetic tools in widespread use today. Generated through the random integration of DNA fragments into the host genome, transgenesis can lead to insertional mutagenesis if a codi...

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Detalles Bibliográficos
Autores principales: Goodwin, Leslie O., Splinter, Erik, Davis, Tiffany L., Urban, Rachel, He, Hao, Braun, Robert E., Chesler, Elissa J., Kumar, Vivek, van Min, Max, Ndukum, Juliet, Philip, Vivek M., Reinholdt, Laura G., Svenson, Karen, White, Jacqueline K., Sasner, Michael, Lutz, Cathleen, Murray, Stephen A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2019
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396414/
https://www.ncbi.nlm.nih.gov/pubmed/30659012
http://dx.doi.org/10.1101/gr.233866.117

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