JACKS: joint analysis of CRISPR/Cas9 knockout screens

Genome-wide CRISPR/Cas9 knockout screens are revolutionizing mammalian functional genomics. However, their range of applications remains limited by signal variability from different guide RNAs that target the same gene, which confounds gene effect estimation and dictates large experiment sizes. To a...

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Detalles Bibliográficos
Autores principales: Allen, Felicity, Behan, Fiona, Khodak, Anton, Iorio, Francesco, Yusa, Kosuke, Garnett, Mathew, Parts, Leopold
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2019
Materias:
Method
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396427/
https://www.ncbi.nlm.nih.gov/pubmed/30674557
http://dx.doi.org/10.1101/gr.238923.118

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396427/
https://www.ncbi.nlm.nih.gov/pubmed/30674557
http://dx.doi.org/10.1101/gr.238923.118

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