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Polyunsaturated fatty acids and child neurodevelopment among a population exposed to DDT: a cohort study
BACKGROUND: Child neurodevelopment has been positively linked to maternal intake of polyunsaturated fatty acids (PUFAs) during pregnancy; however, it is unknown if that relationship persists among populations exposed to environmental neurotoxicants. OBJECTIVE: The aim of this work was to assess whet...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396452/ https://www.ncbi.nlm.nih.gov/pubmed/30819201 http://dx.doi.org/10.1186/s12940-019-0456-8 |
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author | Mérida-Ortega, Ángel Rothenberg, Stephen J. Torres-Sánchez, Luisa Schnaas, Lourdes Hernández-Alcaraz, César Cebrián, Mariano E. García-Hernández, Rosa María Ogaz-González, Rafael López-Carrillo, Lizbeth |
author_facet | Mérida-Ortega, Ángel Rothenberg, Stephen J. Torres-Sánchez, Luisa Schnaas, Lourdes Hernández-Alcaraz, César Cebrián, Mariano E. García-Hernández, Rosa María Ogaz-González, Rafael López-Carrillo, Lizbeth |
author_sort | Mérida-Ortega, Ángel |
collection | PubMed |
description | BACKGROUND: Child neurodevelopment has been positively linked to maternal intake of polyunsaturated fatty acids (PUFAs) during pregnancy; however, it is unknown if that relationship persists among populations exposed to environmental neurotoxicants. OBJECTIVE: The aim of this work was to assess whether maternal dietary intake of PUFAs during pregnancy is positively associated with child neurodevelopment, whose mothers were environmentally exposed to 1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane (DDT). METHODS: A prospective cohort study with 276 mother–child pairs was performed in Mexico. Neurodevelopment was assessed by Bayley Scales II from children age 1 to 30 months. Dietary PUFAs intake was estimated by Food Frequency Questionnaire at 1st and 3rd trimester of pregnancy. DDE (1,1-dichloro-2,2-bis(p-chlorophenyl) ethylene, the main metabolite of DDT) maternal serum levels were determined by electron capture gas chromatography. Longitudinal multivariate linear mixed-effects analysis, which combines mental (MDI) and motor (PDI) Bayley scales in a single model, were performed. RESULTS: Our results show that in a sample environmentally exposed to DDT, maternal ingestion of DPA during the first trimester of pregnancy was positively associated with MDI (β = 0.10, 95% CI 0.02, 0.18) in children from 1 to 30 months. Likewise, our results suggest that dietary ALA may be also related to MDI. CONCLUSION: DPA may benefit neurodevelopment even in populations exposed to DDT. Our results strengthen the importance of PUFAs intake during the prenatal period. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s12940-019-0456-8) contains supplementary material, which is available to authorized users. |
format | Online Article Text |
id | pubmed-6396452 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-63964522019-03-11 Polyunsaturated fatty acids and child neurodevelopment among a population exposed to DDT: a cohort study Mérida-Ortega, Ángel Rothenberg, Stephen J. Torres-Sánchez, Luisa Schnaas, Lourdes Hernández-Alcaraz, César Cebrián, Mariano E. García-Hernández, Rosa María Ogaz-González, Rafael López-Carrillo, Lizbeth Environ Health Research BACKGROUND: Child neurodevelopment has been positively linked to maternal intake of polyunsaturated fatty acids (PUFAs) during pregnancy; however, it is unknown if that relationship persists among populations exposed to environmental neurotoxicants. OBJECTIVE: The aim of this work was to assess whether maternal dietary intake of PUFAs during pregnancy is positively associated with child neurodevelopment, whose mothers were environmentally exposed to 1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane (DDT). METHODS: A prospective cohort study with 276 mother–child pairs was performed in Mexico. Neurodevelopment was assessed by Bayley Scales II from children age 1 to 30 months. Dietary PUFAs intake was estimated by Food Frequency Questionnaire at 1st and 3rd trimester of pregnancy. DDE (1,1-dichloro-2,2-bis(p-chlorophenyl) ethylene, the main metabolite of DDT) maternal serum levels were determined by electron capture gas chromatography. Longitudinal multivariate linear mixed-effects analysis, which combines mental (MDI) and motor (PDI) Bayley scales in a single model, were performed. RESULTS: Our results show that in a sample environmentally exposed to DDT, maternal ingestion of DPA during the first trimester of pregnancy was positively associated with MDI (β = 0.10, 95% CI 0.02, 0.18) in children from 1 to 30 months. Likewise, our results suggest that dietary ALA may be also related to MDI. CONCLUSION: DPA may benefit neurodevelopment even in populations exposed to DDT. Our results strengthen the importance of PUFAs intake during the prenatal period. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s12940-019-0456-8) contains supplementary material, which is available to authorized users. BioMed Central 2019-02-28 /pmc/articles/PMC6396452/ /pubmed/30819201 http://dx.doi.org/10.1186/s12940-019-0456-8 Text en © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Mérida-Ortega, Ángel Rothenberg, Stephen J. Torres-Sánchez, Luisa Schnaas, Lourdes Hernández-Alcaraz, César Cebrián, Mariano E. García-Hernández, Rosa María Ogaz-González, Rafael López-Carrillo, Lizbeth Polyunsaturated fatty acids and child neurodevelopment among a population exposed to DDT: a cohort study |
title | Polyunsaturated fatty acids and child neurodevelopment among a population exposed to DDT: a cohort study |
title_full | Polyunsaturated fatty acids and child neurodevelopment among a population exposed to DDT: a cohort study |
title_fullStr | Polyunsaturated fatty acids and child neurodevelopment among a population exposed to DDT: a cohort study |
title_full_unstemmed | Polyunsaturated fatty acids and child neurodevelopment among a population exposed to DDT: a cohort study |
title_short | Polyunsaturated fatty acids and child neurodevelopment among a population exposed to DDT: a cohort study |
title_sort | polyunsaturated fatty acids and child neurodevelopment among a population exposed to ddt: a cohort study |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396452/ https://www.ncbi.nlm.nih.gov/pubmed/30819201 http://dx.doi.org/10.1186/s12940-019-0456-8 |
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