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Treatment patterns and burden of behavioral disturbances in patients with dementia in the United States: a claims database analysis

BACKGROUND: Although patients with dementia frequently experience neuropsychological symptoms (NPS) such as agitation, which profoundly impacts patients, caregivers, and the healthcare system, few studies have evaluated the associated burden of agitation or agitation-related symptoms in dementia. ME...

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Autores principales: Aigbogun, Myrlene Sanon, Stellhorn, Robert, Hartry, Ann, Baker, Ross A., Fillit, Howard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396493/
https://www.ncbi.nlm.nih.gov/pubmed/30819136
http://dx.doi.org/10.1186/s12883-019-1260-3
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author Aigbogun, Myrlene Sanon
Stellhorn, Robert
Hartry, Ann
Baker, Ross A.
Fillit, Howard
author_facet Aigbogun, Myrlene Sanon
Stellhorn, Robert
Hartry, Ann
Baker, Ross A.
Fillit, Howard
author_sort Aigbogun, Myrlene Sanon
collection PubMed
description BACKGROUND: Although patients with dementia frequently experience neuropsychological symptoms (NPS) such as agitation, which profoundly impacts patients, caregivers, and the healthcare system, few studies have evaluated the associated burden of agitation or agitation-related symptoms in dementia. METHODS: This retrospective analysis of claims data from the Truven Health MarketScan® database (2012–2015) compared clinical characteristics, treatment patterns, healthcare resource utilization, and costs among patients with dementia with behavioral disturbances (BD) versus patients with dementia without BD. Existing BD diagnosis codes 294.11 or 294.21 were used as a means to identify patients with agitation/agitation-related symptoms. RESULTS: From a starting sample of 6.4 million beneficiaries, 103,402 patients with dementia were identified, of whom 16,440 (16%) had BD during an average of 17 months of follow-up. Patients with BD had significantly more medical and psychiatric comorbidities and greater comedication use (i.e., antidementia drugs, antidepressants, and antipsychotics; all values, P < .0001) compared with patients without BD. A significantly greater number of hospitalizations, hospital days, outpatient hospital/clinic visits, number of skilled nursing visits, and number of patients with hospice visit were reported during follow-up in patients with BD compared with patients without BD (all values, P <  0.0001). Costs were also significantly higher among patients with BD versus those patients without BD ($42,284 vs. $32,640, respectively; P <  0.0001). CONCLUSIONS: Patients with dementia with BD had a higher prevalence of comorbidities, greater use of comedications, and greater healthcare utilization and costs than patients with dementia without BD. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s12883-019-1260-3) contains supplementary material, which is available to authorized users.
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spelling pubmed-63964932019-03-13 Treatment patterns and burden of behavioral disturbances in patients with dementia in the United States: a claims database analysis Aigbogun, Myrlene Sanon Stellhorn, Robert Hartry, Ann Baker, Ross A. Fillit, Howard BMC Neurol Research Article BACKGROUND: Although patients with dementia frequently experience neuropsychological symptoms (NPS) such as agitation, which profoundly impacts patients, caregivers, and the healthcare system, few studies have evaluated the associated burden of agitation or agitation-related symptoms in dementia. METHODS: This retrospective analysis of claims data from the Truven Health MarketScan® database (2012–2015) compared clinical characteristics, treatment patterns, healthcare resource utilization, and costs among patients with dementia with behavioral disturbances (BD) versus patients with dementia without BD. Existing BD diagnosis codes 294.11 or 294.21 were used as a means to identify patients with agitation/agitation-related symptoms. RESULTS: From a starting sample of 6.4 million beneficiaries, 103,402 patients with dementia were identified, of whom 16,440 (16%) had BD during an average of 17 months of follow-up. Patients with BD had significantly more medical and psychiatric comorbidities and greater comedication use (i.e., antidementia drugs, antidepressants, and antipsychotics; all values, P < .0001) compared with patients without BD. A significantly greater number of hospitalizations, hospital days, outpatient hospital/clinic visits, number of skilled nursing visits, and number of patients with hospice visit were reported during follow-up in patients with BD compared with patients without BD (all values, P <  0.0001). Costs were also significantly higher among patients with BD versus those patients without BD ($42,284 vs. $32,640, respectively; P <  0.0001). CONCLUSIONS: Patients with dementia with BD had a higher prevalence of comorbidities, greater use of comedications, and greater healthcare utilization and costs than patients with dementia without BD. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s12883-019-1260-3) contains supplementary material, which is available to authorized users. BioMed Central 2019-02-28 /pmc/articles/PMC6396493/ /pubmed/30819136 http://dx.doi.org/10.1186/s12883-019-1260-3 Text en © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Aigbogun, Myrlene Sanon
Stellhorn, Robert
Hartry, Ann
Baker, Ross A.
Fillit, Howard
Treatment patterns and burden of behavioral disturbances in patients with dementia in the United States: a claims database analysis
title Treatment patterns and burden of behavioral disturbances in patients with dementia in the United States: a claims database analysis
title_full Treatment patterns and burden of behavioral disturbances in patients with dementia in the United States: a claims database analysis
title_fullStr Treatment patterns and burden of behavioral disturbances in patients with dementia in the United States: a claims database analysis
title_full_unstemmed Treatment patterns and burden of behavioral disturbances in patients with dementia in the United States: a claims database analysis
title_short Treatment patterns and burden of behavioral disturbances in patients with dementia in the United States: a claims database analysis
title_sort treatment patterns and burden of behavioral disturbances in patients with dementia in the united states: a claims database analysis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396493/
https://www.ncbi.nlm.nih.gov/pubmed/30819136
http://dx.doi.org/10.1186/s12883-019-1260-3
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