Exploring the unique function of imprinting control centers in the PWS/AS-responsible region: finding from array-based methylation analysis in cases with variously sized microdeletions

BACKGROUND: Human 15q11–13 is responsible for Prader-Willi syndrome (PWS) and Angelman syndrome (AS) and includes several imprinted genes together with bipartite elements named AS-IC (imprinting center) and PWS-IC. These concertedly confer allele specificity on 15q11–13. Here, we report DNA methylat...

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Detalles Bibliográficos
Autores principales: Matsubara, Keiko, Itoh, Masatsune, Shimizu, Kenji, Saito, Shinji, Enomoto, Keisuke, Nakabayashi, Kazuhiko, Hata, Kenichiro, Kurosawa, Kenji, Ogata, Tsutomu, Fukami, Maki, Kagami, Masayo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396496/
https://www.ncbi.nlm.nih.gov/pubmed/30819260
http://dx.doi.org/10.1186/s13148-019-0633-1

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