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Frequency & predictors of pancreatitis in symptomatic primary hyperparathyroidism
BACKGROUND & OBJECTIVES: The frequency and predictors of pancreatitis in primary hyperparathyroidism (PHPT) are not well understood. The objective of the present study was to evaluate the frequency of pancreatitis in patients with PHPT and its association with clinical and biochemical parameters...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Medknow Publications & Media Pvt Ltd
2018
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396558/ https://www.ncbi.nlm.nih.gov/pubmed/30778006 http://dx.doi.org/10.4103/ijmr.IJMR_353_16 |
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author | Arya, Ashutosh Kumar Bhadada, Sanjay Kumar Mukherjee, Soham Singh, Priyanka Rana, Surinder S. Dahiya, Divya Sood, Ashwani Saikia, Uma Nahar Prakash, Mahesh Bhasin, Deepak Kumar Behera, Arunanshu Walia, Rama Bhansali, Anil |
author_facet | Arya, Ashutosh Kumar Bhadada, Sanjay Kumar Mukherjee, Soham Singh, Priyanka Rana, Surinder S. Dahiya, Divya Sood, Ashwani Saikia, Uma Nahar Prakash, Mahesh Bhasin, Deepak Kumar Behera, Arunanshu Walia, Rama Bhansali, Anil |
author_sort | Arya, Ashutosh Kumar |
collection | PubMed |
description | BACKGROUND & OBJECTIVES: The frequency and predictors of pancreatitis in primary hyperparathyroidism (PHPT) are not well understood. The objective of the present study was to evaluate the frequency of pancreatitis in patients with PHPT and its association with clinical and biochemical parameters of the disease. METHODS: In this retrospective study all consecutive patients with PHPT registered in the PHPT registry (www.indianphptregistry.com) from the year 2004 to 2013 were included. The clinical, biochemical and radiological parameters related to pancreatitis were evaluated in histologically proven PHPT patients. RESULTS: A total of 218 patients (63 men; mean age: 40.6±14.4 yr) underwent surgery for PHPT during the study. Pancreatitis occurred in 35 [16%, 18 acute and 17 chronic pancreatitis (CP)] patients and male:female ratio was 1:0.94. Skeletal manifestations were seen less frequently in PHPT with pancreatitis as compared to that of PHPT without pancreatitis. PHPT with pancreatitis had significantly higher serum calcium (12.4±2.0 vs. 11.7±1.5 mg/dl, P<0.05) in comparison to PHPT without pancreatitis. PHPT with acute pancreatitis (AP) had higher serum calcium (P<0.05) and parathyroid hormone (PTH) (P<0.05) levels than PHPT with CP. Curative parathyroidectomy improved the symptoms associated with pancreatitis as there was no recurrence in AP group, whereas recurrence was observed only in about 10 per cent patients of the CP group. INTERPRETATION & CONCLUSIONS: Pancreatitis was observed in 16 per cent of PHPT patients with male predominance in the study population. No recurrence of AP was observed after curative surgery. It may be proposed that serum amylase with calcium and PTH should be measured in all patients of PHPT with pain abdomen to rule out pancreatitis. |
format | Online Article Text |
id | pubmed-6396558 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-63965582019-03-25 Frequency & predictors of pancreatitis in symptomatic primary hyperparathyroidism Arya, Ashutosh Kumar Bhadada, Sanjay Kumar Mukherjee, Soham Singh, Priyanka Rana, Surinder S. Dahiya, Divya Sood, Ashwani Saikia, Uma Nahar Prakash, Mahesh Bhasin, Deepak Kumar Behera, Arunanshu Walia, Rama Bhansali, Anil Indian J Med Res Original Article BACKGROUND & OBJECTIVES: The frequency and predictors of pancreatitis in primary hyperparathyroidism (PHPT) are not well understood. The objective of the present study was to evaluate the frequency of pancreatitis in patients with PHPT and its association with clinical and biochemical parameters of the disease. METHODS: In this retrospective study all consecutive patients with PHPT registered in the PHPT registry (www.indianphptregistry.com) from the year 2004 to 2013 were included. The clinical, biochemical and radiological parameters related to pancreatitis were evaluated in histologically proven PHPT patients. RESULTS: A total of 218 patients (63 men; mean age: 40.6±14.4 yr) underwent surgery for PHPT during the study. Pancreatitis occurred in 35 [16%, 18 acute and 17 chronic pancreatitis (CP)] patients and male:female ratio was 1:0.94. Skeletal manifestations were seen less frequently in PHPT with pancreatitis as compared to that of PHPT without pancreatitis. PHPT with pancreatitis had significantly higher serum calcium (12.4±2.0 vs. 11.7±1.5 mg/dl, P<0.05) in comparison to PHPT without pancreatitis. PHPT with acute pancreatitis (AP) had higher serum calcium (P<0.05) and parathyroid hormone (PTH) (P<0.05) levels than PHPT with CP. Curative parathyroidectomy improved the symptoms associated with pancreatitis as there was no recurrence in AP group, whereas recurrence was observed only in about 10 per cent patients of the CP group. INTERPRETATION & CONCLUSIONS: Pancreatitis was observed in 16 per cent of PHPT patients with male predominance in the study population. No recurrence of AP was observed after curative surgery. It may be proposed that serum amylase with calcium and PTH should be measured in all patients of PHPT with pain abdomen to rule out pancreatitis. Medknow Publications & Media Pvt Ltd 2018-12 /pmc/articles/PMC6396558/ /pubmed/30778006 http://dx.doi.org/10.4103/ijmr.IJMR_353_16 Text en Copyright: © 2019 Indian Journal of Medical Research http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms. |
spellingShingle | Original Article Arya, Ashutosh Kumar Bhadada, Sanjay Kumar Mukherjee, Soham Singh, Priyanka Rana, Surinder S. Dahiya, Divya Sood, Ashwani Saikia, Uma Nahar Prakash, Mahesh Bhasin, Deepak Kumar Behera, Arunanshu Walia, Rama Bhansali, Anil Frequency & predictors of pancreatitis in symptomatic primary hyperparathyroidism |
title | Frequency & predictors of pancreatitis in symptomatic primary hyperparathyroidism |
title_full | Frequency & predictors of pancreatitis in symptomatic primary hyperparathyroidism |
title_fullStr | Frequency & predictors of pancreatitis in symptomatic primary hyperparathyroidism |
title_full_unstemmed | Frequency & predictors of pancreatitis in symptomatic primary hyperparathyroidism |
title_short | Frequency & predictors of pancreatitis in symptomatic primary hyperparathyroidism |
title_sort | frequency & predictors of pancreatitis in symptomatic primary hyperparathyroidism |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396558/ https://www.ncbi.nlm.nih.gov/pubmed/30778006 http://dx.doi.org/10.4103/ijmr.IJMR_353_16 |
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