Cargando…
Natural Infection with Rabies Virus: A Histopathological and Immunohistochemical Study of Human Brains
OBJECTIVES: Despite all the efforts and increased knowledge of rabies, the exact mechanisms of infection and mortality from the rabies virus are not well understood. To understand the mechanisms underlying the pathogenicity of rabies virus infection, it is crucial to study the tissue that the rabies...
Autores principales: | , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Korea Centers for Disease Control and Prevention
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396821/ https://www.ncbi.nlm.nih.gov/pubmed/30847265 http://dx.doi.org/10.24171/j.phrp.2019.10.1.03 |
_version_ | 1783399327494832128 |
---|---|
author | Farahtaj, Firouzeh Alizadeh, Leila Gholami, Alireza Tahamtan, Alireza Shirian, Sadegh Fazeli, Maryam Nejad, Amir Sasan Mozaffari Gorji, Ali Niknam, Hamid Mahmoudzadeh Ghaemi, Amir |
author_facet | Farahtaj, Firouzeh Alizadeh, Leila Gholami, Alireza Tahamtan, Alireza Shirian, Sadegh Fazeli, Maryam Nejad, Amir Sasan Mozaffari Gorji, Ali Niknam, Hamid Mahmoudzadeh Ghaemi, Amir |
author_sort | Farahtaj, Firouzeh |
collection | PubMed |
description | OBJECTIVES: Despite all the efforts and increased knowledge of rabies, the exact mechanisms of infection and mortality from the rabies virus are not well understood. To understand the mechanisms underlying the pathogenicity of rabies virus infection, it is crucial to study the tissue that the rabies virus naturally infects in humans. METHODS: Cerebellum brain tissue from 9 human post mortem cases from Iran, who had been infected with rabies virus, were examined histopathologically and immunohistochemically to evaluate the innate immune responses against the rabies virus. RESULTS: Histopathological examination revealed inflammation of the infected cerebellum and immunohistochemical analyses showed an increased immunoreactivity of heat shock protein 70, interleukin-6, interleukin-1, tumor necrosis factor-alpha, caspase-3, caspase-9, toll-like receptor3 and toll-like receptor4 in the infected brain tissue. CONCLUSION: These results indicated the involvement of innate immunity in rabies infected human brain tissue, which may aggravate the progression of this deadly disease. |
format | Online Article Text |
id | pubmed-6396821 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Korea Centers for Disease Control and Prevention |
record_format | MEDLINE/PubMed |
spelling | pubmed-63968212019-03-07 Natural Infection with Rabies Virus: A Histopathological and Immunohistochemical Study of Human Brains Farahtaj, Firouzeh Alizadeh, Leila Gholami, Alireza Tahamtan, Alireza Shirian, Sadegh Fazeli, Maryam Nejad, Amir Sasan Mozaffari Gorji, Ali Niknam, Hamid Mahmoudzadeh Ghaemi, Amir Osong Public Health Res Perspect Original Article OBJECTIVES: Despite all the efforts and increased knowledge of rabies, the exact mechanisms of infection and mortality from the rabies virus are not well understood. To understand the mechanisms underlying the pathogenicity of rabies virus infection, it is crucial to study the tissue that the rabies virus naturally infects in humans. METHODS: Cerebellum brain tissue from 9 human post mortem cases from Iran, who had been infected with rabies virus, were examined histopathologically and immunohistochemically to evaluate the innate immune responses against the rabies virus. RESULTS: Histopathological examination revealed inflammation of the infected cerebellum and immunohistochemical analyses showed an increased immunoreactivity of heat shock protein 70, interleukin-6, interleukin-1, tumor necrosis factor-alpha, caspase-3, caspase-9, toll-like receptor3 and toll-like receptor4 in the infected brain tissue. CONCLUSION: These results indicated the involvement of innate immunity in rabies infected human brain tissue, which may aggravate the progression of this deadly disease. Korea Centers for Disease Control and Prevention 2019-02 /pmc/articles/PMC6396821/ /pubmed/30847265 http://dx.doi.org/10.24171/j.phrp.2019.10.1.03 Text en Copyright ©2019, Korea Centers for Disease Control and Prevention http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Original Article Farahtaj, Firouzeh Alizadeh, Leila Gholami, Alireza Tahamtan, Alireza Shirian, Sadegh Fazeli, Maryam Nejad, Amir Sasan Mozaffari Gorji, Ali Niknam, Hamid Mahmoudzadeh Ghaemi, Amir Natural Infection with Rabies Virus: A Histopathological and Immunohistochemical Study of Human Brains |
title | Natural Infection with Rabies Virus: A Histopathological and Immunohistochemical Study of Human Brains |
title_full | Natural Infection with Rabies Virus: A Histopathological and Immunohistochemical Study of Human Brains |
title_fullStr | Natural Infection with Rabies Virus: A Histopathological and Immunohistochemical Study of Human Brains |
title_full_unstemmed | Natural Infection with Rabies Virus: A Histopathological and Immunohistochemical Study of Human Brains |
title_short | Natural Infection with Rabies Virus: A Histopathological and Immunohistochemical Study of Human Brains |
title_sort | natural infection with rabies virus: a histopathological and immunohistochemical study of human brains |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396821/ https://www.ncbi.nlm.nih.gov/pubmed/30847265 http://dx.doi.org/10.24171/j.phrp.2019.10.1.03 |
work_keys_str_mv | AT farahtajfirouzeh naturalinfectionwithrabiesvirusahistopathologicalandimmunohistochemicalstudyofhumanbrains AT alizadehleila naturalinfectionwithrabiesvirusahistopathologicalandimmunohistochemicalstudyofhumanbrains AT gholamialireza naturalinfectionwithrabiesvirusahistopathologicalandimmunohistochemicalstudyofhumanbrains AT tahamtanalireza naturalinfectionwithrabiesvirusahistopathologicalandimmunohistochemicalstudyofhumanbrains AT shiriansadegh naturalinfectionwithrabiesvirusahistopathologicalandimmunohistochemicalstudyofhumanbrains AT fazelimaryam naturalinfectionwithrabiesvirusahistopathologicalandimmunohistochemicalstudyofhumanbrains AT nejadamirsasanmozaffari naturalinfectionwithrabiesvirusahistopathologicalandimmunohistochemicalstudyofhumanbrains AT gorjiali naturalinfectionwithrabiesvirusahistopathologicalandimmunohistochemicalstudyofhumanbrains AT niknamhamidmahmoudzadeh naturalinfectionwithrabiesvirusahistopathologicalandimmunohistochemicalstudyofhumanbrains AT ghaemiamir naturalinfectionwithrabiesvirusahistopathologicalandimmunohistochemicalstudyofhumanbrains |