Atomic structures and deletion mutant reveal different capsid-binding patterns and functional significance of tegument protein pp150 in murine and human cytomegaloviruses with implications for therapeutic development

Cytomegalovirus (CMV) infection causes birth defects and life-threatening complications in immunosuppressed patients. Lack of vaccine and need for more effective drugs have driven widespread ongoing therapeutic development efforts against human CMV (HCMV), mostly using murine CMV (MCMV) as the model...

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Detalles Bibliográficos
Autores principales: Liu, Wei, Dai, Xinghong, Jih, Jonathan, Chan, Karen, Trang, Phong, Yu, Xuekui, Balogun, Rilwan, Mei, Ye, Liu, Fenyong, Zhou, Z. Hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396938/
https://www.ncbi.nlm.nih.gov/pubmed/30779794
http://dx.doi.org/10.1371/journal.ppat.1007615

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