Cul4-Ddb1 ubiquitin ligases facilitate DNA replication-coupled sister chromatid cohesion through regulation of cohesin acetyltransferase Esco2

Cohesin acetyltransferases ESCO1 and ESCO2 play a vital role in establishing sister chromatid cohesion. How ESCO1 and ESCO2 are controlled in a DNA replication-coupled manner remains unclear in higher eukaryotes. Here we show a critical role of CUL4-RING ligases (CRL4s) in cohesion establishment via...

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Detalles Bibliográficos
Autores principales: Sun, Haitao, Zhang, Jiaxin, Xin, Siyu, Jiang, Meiqian, Zhang, Jingjing, Li, Zhen, Cao, Qinhong, Lou, Huiqiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396947/
https://www.ncbi.nlm.nih.gov/pubmed/30779731
http://dx.doi.org/10.1371/journal.pgen.1007685

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