A Naturally Occurring Polymorphism in the HIV-1 Tat Basic Domain Inhibits Uptake by Bystander Cells and Leads to Reduced Neuroinflammation

HIV-1 Tat protein contributes to HIV-neuropathogenesis in several ways including its ability to be taken up by uninfected bystander CNS cells and to activate inflammatory host genes causing synaptic injury. Here, we report that in the globally dominant HIV-1 clade C, Tat displays a naturally occurri...

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Detalles Bibliográficos
Autores principales: Ruiz, Arthur P., Ajasin, David O., Ramasamy, Santhamani, DesMarais, Vera, Eugenin, Eliseo A., Prasad, Vinayaka R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6397180/
https://www.ncbi.nlm.nih.gov/pubmed/30824746
http://dx.doi.org/10.1038/s41598-019-39531-5

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