Murine osteoclasts secrete serine protease HtrA1 capable of degrading osteoprotegerin in the bone microenvironment

Osteoclasts are multinucleated cells responsible for bone resorption. The differentiation of osteoclasts from bone marrow macrophages (BMMs) is induced by receptor activator of NF-κB ligand (RANKL). Osteoprotegerin (OPG), a decoy receptor of RANKL, inhibits osteoclastogenesis by blocking RANKL signa...

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Detalles Bibliográficos
Autores principales: Ochiai, Nagahiro, Nakachi, Yutaka, Yokoo, Tomotaka, Ichihara, Takahiro, Eriksson, Tore, Yonemoto, Yuki, Kato, Takehiko, Ogata, Hitoshi, Fujimoto, Natsuko, Kobayashi, Yasuhiro, Udagawa, Nobuyuki, Kaku, Shinsuke, Ueki, Tomokazu, Okazaki, Yasushi, Takahashi, Naoyuki, Suda, Tatsuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6397181/
https://www.ncbi.nlm.nih.gov/pubmed/30854478
http://dx.doi.org/10.1038/s42003-019-0334-5

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