Targeted delivery of TLR3 agonist to tumor cells with single chain antibody fragment-conjugated nanoparticles induces type I-interferon response and apoptosis

Application of Toll-like receptor (TLR) agonists is a promising approach to treat cancer. In particular, nucleic acid-based TLR agonists such as short ssRNA and dsRNA molecules, which activate endosomal TLRs, can be delivered to tumors by use of nanoparticle delivery systems. However, such delivery...

Descripción completa

Detalles Bibliográficos
Autores principales: Schau, Isabell, Michen, Susanne, Hagstotz, Alexander, Janke, Andreas, Schackert, Gabriele, Appelhans, Dietmar, Temme, Achim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6397204/
https://www.ncbi.nlm.nih.gov/pubmed/30824859
http://dx.doi.org/10.1038/s41598-019-40032-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6397204/
https://www.ncbi.nlm.nih.gov/pubmed/30824859
http://dx.doi.org/10.1038/s41598-019-40032-8

Ejemplares similares