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Selecting variants of unknown significance through network-based gene-association significantly improves risk prediction for disease-control cohorts
Variants of unknown/uncertain significance (VUS) pose a huge dilemma in current genetic variation screening methods and genetic counselling. Driven by methods of next generation sequencing (NGS) such as whole exome sequencing (WES), a plethora of VUS are being detected in research laboratories as we...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6397233/ https://www.ncbi.nlm.nih.gov/pubmed/30824863 http://dx.doi.org/10.1038/s41598-019-39796-w |