Intracellular delivery of mRNA to human primary T cells with microfluidic vortex shedding

Intracellular delivery of functional macromolecules, such as DNA and RNA, across the cell membrane and into the cytosol, is a critical process in both biology and medicine. Herein, we develop and use microfluidic chips containing post arrays to induce microfluidic vortex shedding, or μVS, for cell m...

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Detalles Bibliográficos
Autores principales: Jarrell, Justin A., Twite, Amy A., Lau, Katherine H. W. J., Kashani, Moein N., Lievano, Adrian A., Acevedo, Julyana, Priest, Craig, Nieva, Jorge, Gottlieb, David, Pawell, Ryan S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6397276/
https://www.ncbi.nlm.nih.gov/pubmed/30824814
http://dx.doi.org/10.1038/s41598-019-40147-y

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