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Inflammatory cytokines and change of Th1/Th2 balance as prognostic indicators for hepatocellular carcinoma in patients treated with transarterial chemoembolization

Tumor-associated immune response plays a critical role in cancer pathogenesis. This study evaluated clinical implications of T cell cytokines and regulatory T cells (Tregs) in HCC patients treated with TACE. Whole blood was obtained for analysis of T cell cytokines (IL-1β, IL-2, IL-4, IL-5, IL-6, IL...

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Autores principales: Lee, Hae Lim, Jang, Jeong Won, Lee, Sung Won, Yoo, Sun Hong, Kwon, Jung Hyun, Nam, Soon Woo, Bae, Si Hyun, Choi, Jong Young, Han, Nam Ik, Yoon, Seung Kew
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6397294/
https://www.ncbi.nlm.nih.gov/pubmed/30824840
http://dx.doi.org/10.1038/s41598-019-40078-8
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author Lee, Hae Lim
Jang, Jeong Won
Lee, Sung Won
Yoo, Sun Hong
Kwon, Jung Hyun
Nam, Soon Woo
Bae, Si Hyun
Choi, Jong Young
Han, Nam Ik
Yoon, Seung Kew
author_facet Lee, Hae Lim
Jang, Jeong Won
Lee, Sung Won
Yoo, Sun Hong
Kwon, Jung Hyun
Nam, Soon Woo
Bae, Si Hyun
Choi, Jong Young
Han, Nam Ik
Yoon, Seung Kew
author_sort Lee, Hae Lim
collection PubMed
description Tumor-associated immune response plays a critical role in cancer pathogenesis. This study evaluated clinical implications of T cell cytokines and regulatory T cells (Tregs) in HCC patients treated with TACE. Whole blood was obtained for analysis of T cell cytokines (IL-1β, IL-2, IL-4, IL-5, IL-6, IL-9, IL-10, IL-12p70, IL-13, IL-17A, IL-22, IFN-γ, and TNF-α) and Tregs from 142 HCC patients. Patients with CTP class A had a significantly lower proportion of detectable IL-4 or IL-6, but a higher proportion of detectable IL-22 than patients with CTP class B/C. IL-6 level was well correlated with tumor stage and undetectable IL-17A was associated with extrahepatic metastasis. The overall survival rate was significantly higher in patients who had undetectable IL-6 or detectable IL-22 than patients who did not. IL-6 among cytokines remained independently predictive factor for survival. Increased IFN-γ/IL-10 ratio and no increase in IL-6 level following TACE were associated with prolonged survival, and baseline Tregs could affect Th1/Th2 balance. T cell cytokines are associated with a variety of clinical aspects of HCC, and IL-6 is the most significant predictor of survival. A shift toward increased Th1 response and no increase in IL-6 level exert favorable immunologic effects on HCC prognosis.
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spelling pubmed-63972942019-03-05 Inflammatory cytokines and change of Th1/Th2 balance as prognostic indicators for hepatocellular carcinoma in patients treated with transarterial chemoembolization Lee, Hae Lim Jang, Jeong Won Lee, Sung Won Yoo, Sun Hong Kwon, Jung Hyun Nam, Soon Woo Bae, Si Hyun Choi, Jong Young Han, Nam Ik Yoon, Seung Kew Sci Rep Article Tumor-associated immune response plays a critical role in cancer pathogenesis. This study evaluated clinical implications of T cell cytokines and regulatory T cells (Tregs) in HCC patients treated with TACE. Whole blood was obtained for analysis of T cell cytokines (IL-1β, IL-2, IL-4, IL-5, IL-6, IL-9, IL-10, IL-12p70, IL-13, IL-17A, IL-22, IFN-γ, and TNF-α) and Tregs from 142 HCC patients. Patients with CTP class A had a significantly lower proportion of detectable IL-4 or IL-6, but a higher proportion of detectable IL-22 than patients with CTP class B/C. IL-6 level was well correlated with tumor stage and undetectable IL-17A was associated with extrahepatic metastasis. The overall survival rate was significantly higher in patients who had undetectable IL-6 or detectable IL-22 than patients who did not. IL-6 among cytokines remained independently predictive factor for survival. Increased IFN-γ/IL-10 ratio and no increase in IL-6 level following TACE were associated with prolonged survival, and baseline Tregs could affect Th1/Th2 balance. T cell cytokines are associated with a variety of clinical aspects of HCC, and IL-6 is the most significant predictor of survival. A shift toward increased Th1 response and no increase in IL-6 level exert favorable immunologic effects on HCC prognosis. Nature Publishing Group UK 2019-03-01 /pmc/articles/PMC6397294/ /pubmed/30824840 http://dx.doi.org/10.1038/s41598-019-40078-8 Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Lee, Hae Lim
Jang, Jeong Won
Lee, Sung Won
Yoo, Sun Hong
Kwon, Jung Hyun
Nam, Soon Woo
Bae, Si Hyun
Choi, Jong Young
Han, Nam Ik
Yoon, Seung Kew
Inflammatory cytokines and change of Th1/Th2 balance as prognostic indicators for hepatocellular carcinoma in patients treated with transarterial chemoembolization
title Inflammatory cytokines and change of Th1/Th2 balance as prognostic indicators for hepatocellular carcinoma in patients treated with transarterial chemoembolization
title_full Inflammatory cytokines and change of Th1/Th2 balance as prognostic indicators for hepatocellular carcinoma in patients treated with transarterial chemoembolization
title_fullStr Inflammatory cytokines and change of Th1/Th2 balance as prognostic indicators for hepatocellular carcinoma in patients treated with transarterial chemoembolization
title_full_unstemmed Inflammatory cytokines and change of Th1/Th2 balance as prognostic indicators for hepatocellular carcinoma in patients treated with transarterial chemoembolization
title_short Inflammatory cytokines and change of Th1/Th2 balance as prognostic indicators for hepatocellular carcinoma in patients treated with transarterial chemoembolization
title_sort inflammatory cytokines and change of th1/th2 balance as prognostic indicators for hepatocellular carcinoma in patients treated with transarterial chemoembolization
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6397294/
https://www.ncbi.nlm.nih.gov/pubmed/30824840
http://dx.doi.org/10.1038/s41598-019-40078-8
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