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Identification of genetic alterations associated with primary resistance to EGFR-TKIs in advanced non-small-cell lung cancer patients with EGFR sensitive mutations

BACKGROUND: Identification of activated epidermal growth factor receptor (EGFR) mutations and application of EGFR-tyrosine kinase inhibitors (EGFR-TKIs) have greatly changed the therapeutic strategies of non-small-cell lung cancer (NSCLC). However, the long-term efficacy of EGFR-TKI therapy is limit...

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Detalles Bibliográficos
Autores principales:	Wang, Fang, Diao, Xia-Yao, Zhang, Xiao, Shao, Qiong, Feng, Yan-Fen, An, Xin, Wang, Hai-Yun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6397445/ https://www.ncbi.nlm.nih.gov/pubmed/30823937 http://dx.doi.org/10.1186/s40880-019-0354-z

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