Genome-scale network model of metabolism and histone acetylation reveals metabolic dependencies of histone deacetylase inhibitors

Histone acetylation plays a central role in gene regulation and is sensitive to the levels of metabolic intermediates. However, predicting the impact of metabolic alterations on acetylation in pathological conditions is a significant challenge. Here, we present a genome-scale network model that pred...

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Detalles Bibliográficos
Autores principales: Shen, Fangzhou, Boccuto, Luigi, Pauly, Rini, Srikanth, Sujata, Chandrasekaran, Sriram
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Method
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6397465/
https://www.ncbi.nlm.nih.gov/pubmed/30823893
http://dx.doi.org/10.1186/s13059-019-1661-z

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