Klebsiella oxytoca enterotoxins tilimycin and tilivalline have distinct host DNA-damaging and microtubule-stabilizing activities

Establishing causal links between bacterial metabolites and human intestinal disease is a significant challenge. This study reveals the molecular basis of antibiotic-associated hemorrhagic colitis (AAHC) caused by intestinal resident Klebsiella oxytoca. Colitogenic strains produce the nonribosomal p...

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Detalles Bibliográficos
Autores principales: Unterhauser, Katrin, Pöltl, Lisa, Schneditz, Georg, Kienesberger, Sabine, Glabonjat, Ronald A., Kitsera, Maksym, Pletz, Jakob, Josa-Prado, Fernando, Dornisch, Elisabeth, Lembacher-Fadum, Christian, Roier, Sandro, Gorkiewicz, Gregor, Lucena, Daniel, Barasoain, Isabel, Kroutil, Wolfgang, Wiedner, Marc, Loizou, Joanna I., Breinbauer, Rolf, Díaz, José Fernando, Schild, Stefan, Högenauer, Christoph, Zechner, Ellen L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2019
Materias:
PNAS Plus
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6397511/
https://www.ncbi.nlm.nih.gov/pubmed/30808763
http://dx.doi.org/10.1073/pnas.1819154116

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6397511/
https://www.ncbi.nlm.nih.gov/pubmed/30808763
http://dx.doi.org/10.1073/pnas.1819154116

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