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Inhibition of EZH2 prevents fibrosis and restores normal angiogenesis in scleroderma

Scleroderma (SSc) is a complex disease that involves activation of the immune system, vascular complications, and tissue fibrosis. The histone methyltransferase enhancer of zeste homolog 2 (EZH2) mediates trimethylation of lysine 27 of histone 3 (H3K27me3), which acts as a repressive epigenetic mark...

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Detalles Bibliográficos
Autores principales:	Tsou, Pei-Suen, Campbell, Phillip, Amin, M. Asif, Coit, Patrick, Miller, Shaylynn, Fox, David A., Khanna, Dinesh, Sawalha, Amr H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2019
Materias:	PNAS Plus
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6397533/ https://www.ncbi.nlm.nih.gov/pubmed/30755532 http://dx.doi.org/10.1073/pnas.1813006116

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