The aquaporin-4 inhibitor AER-271 blocks acute cerebral edema and improves early outcome in a pediatric model of asphyxial cardiac arrest

BACKGROUND: Cerebral edema after cardiac arrest (CA) is associated with increased mortality and unfavorable outcome in children and adults. Aquaporin-4 mediates cerebral water movement and its absence in models of ischemia improves outcome. We investigated early and selective pharmacologic inhibitio...

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Detalles Bibliográficos
Autores principales: Wallisch, Jessica S., Janesko-Feldman, Keri, Alexander, Henry, Jha, Ruchira M., Farr, George W., McGuirk, Paul R., Kline, Anthony E., Jackson, Travis C., Pelletier, Marc F., Clark, Robert S.B., Kochanek, Patrick M., Manole, Mioara D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6397683/
https://www.ncbi.nlm.nih.gov/pubmed/30367162
http://dx.doi.org/10.1038/s41390-018-0215-5

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