Use of Catridecacog in a patient with severe Factor XIII deficiency undergoing surgery

Despite many articles regarding the antihemorrhagic treatment and prophylaxis, there is a lack of experience about how to best conduct major surgical procedures in patients with congenital factor XIII (FXIII) deficiency. Here we report a case of surgery (right inguinal hernia, complicated by heavine...

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Autores principales: Sottilotta, Gianluca, Luise, Francesca, Oriana, Vincenzo, Piromalli, Angela, Santacroce, Rosa, Di Lelio, Alessandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: PAGEPress Publications, Pavia, Italy 2019
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6397991/
https://www.ncbi.nlm.nih.gov/pubmed/30915205
http://dx.doi.org/10.4081/hr.2019.7912
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author Sottilotta, Gianluca
Luise, Francesca
Oriana, Vincenzo
Piromalli, Angela
Santacroce, Rosa
Di Lelio, Alessandra
author_facet Sottilotta, Gianluca
Luise, Francesca
Oriana, Vincenzo
Piromalli, Angela
Santacroce, Rosa
Di Lelio, Alessandra
author_sort Sottilotta, Gianluca
collection PubMed
description Despite many articles regarding the antihemorrhagic treatment and prophylaxis, there is a lack of experience about how to best conduct major surgical procedures in patients with congenital factor XIII (FXIII) deficiency. Here we report a case of surgery (right inguinal hernia, complicated by heaviness and pain) performed in a patient with FXIII deficiency, receiving recombinant FXIII prophylaxis (Catridecacog 35 UI/kg every 28±2 days). Our experience shows that Catridecacog can be used safely and effectively not only for continued prophylaxis but also in surgery and adds to the very limited body of evidence currently available on surgery in this bleeding disorder.
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spelling pubmed-63979912019-03-26 Use of Catridecacog in a patient with severe Factor XIII deficiency undergoing surgery Sottilotta, Gianluca Luise, Francesca Oriana, Vincenzo Piromalli, Angela Santacroce, Rosa Di Lelio, Alessandra Hematol Rep Case Report Despite many articles regarding the antihemorrhagic treatment and prophylaxis, there is a lack of experience about how to best conduct major surgical procedures in patients with congenital factor XIII (FXIII) deficiency. Here we report a case of surgery (right inguinal hernia, complicated by heaviness and pain) performed in a patient with FXIII deficiency, receiving recombinant FXIII prophylaxis (Catridecacog 35 UI/kg every 28±2 days). Our experience shows that Catridecacog can be used safely and effectively not only for continued prophylaxis but also in surgery and adds to the very limited body of evidence currently available on surgery in this bleeding disorder. PAGEPress Publications, Pavia, Italy 2019-02-19 /pmc/articles/PMC6397991/ /pubmed/30915205 http://dx.doi.org/10.4081/hr.2019.7912 Text en ©Copyright G. Sottilotta, et al., 2019 http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Sottilotta, Gianluca
Luise, Francesca
Oriana, Vincenzo
Piromalli, Angela
Santacroce, Rosa
Di Lelio, Alessandra
Use of Catridecacog in a patient with severe Factor XIII deficiency undergoing surgery
title Use of Catridecacog in a patient with severe Factor XIII deficiency undergoing surgery
title_full Use of Catridecacog in a patient with severe Factor XIII deficiency undergoing surgery
title_fullStr Use of Catridecacog in a patient with severe Factor XIII deficiency undergoing surgery
title_full_unstemmed Use of Catridecacog in a patient with severe Factor XIII deficiency undergoing surgery
title_short Use of Catridecacog in a patient with severe Factor XIII deficiency undergoing surgery
title_sort use of catridecacog in a patient with severe factor xiii deficiency undergoing surgery
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6397991/
https://www.ncbi.nlm.nih.gov/pubmed/30915205
http://dx.doi.org/10.4081/hr.2019.7912
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