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The Level of Serum Albumin Is Associated with Renal Prognosis in Patients with Diabetic Nephropathy

OBJECTIVE: Although hypoalbuminemia is frequently found in most patients with diabetic nephropathy (DN), its relationship to the severity and progression of DN remains largely unknown. Our aim was to investigate the association between the serum albumin levels and clinicopathological features and re...

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Autores principales: Zhang, Junlin, Zhang, Rui, Wang, Yiting, Li, Hanyu, Han, Qianqian, Wu, Yucheng, Wang, Tingli, Liu, Fang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6398001/
https://www.ncbi.nlm.nih.gov/pubmed/30911552
http://dx.doi.org/10.1155/2019/7825804
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author Zhang, Junlin
Zhang, Rui
Wang, Yiting
Li, Hanyu
Han, Qianqian
Wu, Yucheng
Wang, Tingli
Liu, Fang
author_facet Zhang, Junlin
Zhang, Rui
Wang, Yiting
Li, Hanyu
Han, Qianqian
Wu, Yucheng
Wang, Tingli
Liu, Fang
author_sort Zhang, Junlin
collection PubMed
description OBJECTIVE: Although hypoalbuminemia is frequently found in most patients with diabetic nephropathy (DN), its relationship to the severity and progression of DN remains largely unknown. Our aim was to investigate the association between the serum albumin levels and clinicopathological features and renal outcomes in patients with type 2 diabetes mellitus (T2DM) and biopsy-proven DN. MATERIALS AND METHODS: A total of 188 patients with T2DM and biopsy-proven DN followed up for at least one year were enrolled. The patients were divided into four groups based on the albumin levels: normal group: ≥35 g/L (n = 87); mild group: 30-35 g/L (n = 34); moderate group: 25-30 g/L (n = 36); and severe group: <25 g/L (n = 31). The renal outcome was defined by progression to end-stage renal disease. The impact of the serum albumin level on renal survival was estimated using Cox regression analysis. RESULTS: Among the cases, the serum albumin level had a significant correlation with proteinuria, renal function, and glomerular lesions. A multivariate Cox regression analysis indicated that the severity of hypoalbuminemia remained significantly associated with an adverse renal outcome, independent of clinical and histopathological features. In reference to the normal group, the risk of progression to ESRD increased such that the hazard ratio (HR) for the mild group was 2.09 (95% CI, 0.67-6.56, p = 0.205), 6.20 (95% CI, 1.95-19.76, p = 0.002) for the moderate group, and 7.37 (95% CI, 1.24-43.83, p = 0.028) for the severe group. CONCLUSIONS: These findings suggested that hypoalbuminemia was associated with a poorer renal prognosis in patients with T2DM and DN.
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spelling pubmed-63980012019-03-25 The Level of Serum Albumin Is Associated with Renal Prognosis in Patients with Diabetic Nephropathy Zhang, Junlin Zhang, Rui Wang, Yiting Li, Hanyu Han, Qianqian Wu, Yucheng Wang, Tingli Liu, Fang J Diabetes Res Research Article OBJECTIVE: Although hypoalbuminemia is frequently found in most patients with diabetic nephropathy (DN), its relationship to the severity and progression of DN remains largely unknown. Our aim was to investigate the association between the serum albumin levels and clinicopathological features and renal outcomes in patients with type 2 diabetes mellitus (T2DM) and biopsy-proven DN. MATERIALS AND METHODS: A total of 188 patients with T2DM and biopsy-proven DN followed up for at least one year were enrolled. The patients were divided into four groups based on the albumin levels: normal group: ≥35 g/L (n = 87); mild group: 30-35 g/L (n = 34); moderate group: 25-30 g/L (n = 36); and severe group: <25 g/L (n = 31). The renal outcome was defined by progression to end-stage renal disease. The impact of the serum albumin level on renal survival was estimated using Cox regression analysis. RESULTS: Among the cases, the serum albumin level had a significant correlation with proteinuria, renal function, and glomerular lesions. A multivariate Cox regression analysis indicated that the severity of hypoalbuminemia remained significantly associated with an adverse renal outcome, independent of clinical and histopathological features. In reference to the normal group, the risk of progression to ESRD increased such that the hazard ratio (HR) for the mild group was 2.09 (95% CI, 0.67-6.56, p = 0.205), 6.20 (95% CI, 1.95-19.76, p = 0.002) for the moderate group, and 7.37 (95% CI, 1.24-43.83, p = 0.028) for the severe group. CONCLUSIONS: These findings suggested that hypoalbuminemia was associated with a poorer renal prognosis in patients with T2DM and DN. Hindawi 2019-02-17 /pmc/articles/PMC6398001/ /pubmed/30911552 http://dx.doi.org/10.1155/2019/7825804 Text en Copyright © 2019 Junlin Zhang et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Zhang, Junlin
Zhang, Rui
Wang, Yiting
Li, Hanyu
Han, Qianqian
Wu, Yucheng
Wang, Tingli
Liu, Fang
The Level of Serum Albumin Is Associated with Renal Prognosis in Patients with Diabetic Nephropathy
title The Level of Serum Albumin Is Associated with Renal Prognosis in Patients with Diabetic Nephropathy
title_full The Level of Serum Albumin Is Associated with Renal Prognosis in Patients with Diabetic Nephropathy
title_fullStr The Level of Serum Albumin Is Associated with Renal Prognosis in Patients with Diabetic Nephropathy
title_full_unstemmed The Level of Serum Albumin Is Associated with Renal Prognosis in Patients with Diabetic Nephropathy
title_short The Level of Serum Albumin Is Associated with Renal Prognosis in Patients with Diabetic Nephropathy
title_sort level of serum albumin is associated with renal prognosis in patients with diabetic nephropathy
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6398001/
https://www.ncbi.nlm.nih.gov/pubmed/30911552
http://dx.doi.org/10.1155/2019/7825804
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