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Calponin 3 Regulates Cell Invasion and Doxorubicin Resistance in Gastric Cancer

Calponin 3 (CNN3) is an F-actin-binding protein that regulates actin cytoskeletal rearrangement. However, the role of CNN3 in cancer cell invasion and resistance to chemotherapeutic agents has not yet been investigated. The present study was undertaken to investigate whether CNN3 influences cancer-r...

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Autores principales: Hong, Keun-Seok, Kim, Hyemin, Kim, Seon-Hee, Kim, Minju, Yoo, Jiyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6398029/
https://www.ncbi.nlm.nih.gov/pubmed/30911294
http://dx.doi.org/10.1155/2019/3024970
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author Hong, Keun-Seok
Kim, Hyemin
Kim, Seon-Hee
Kim, Minju
Yoo, Jiyun
author_facet Hong, Keun-Seok
Kim, Hyemin
Kim, Seon-Hee
Kim, Minju
Yoo, Jiyun
author_sort Hong, Keun-Seok
collection PubMed
description Calponin 3 (CNN3) is an F-actin-binding protein that regulates actin cytoskeletal rearrangement. However, the role of CNN3 in cancer cell invasion and resistance to chemotherapeutic agents has not yet been investigated. The present study was undertaken to investigate whether CNN3 influences cancer-related phenotypes in gastric cancer. We demonstrate that CNN3 contributes to cell invasion and resistance to doxorubicin in gastric cancer. CNN3 expression was markedly elevated in highly invasive cancer cell lines compared to less invasive or noninvasive cancer cell lines. Depletion of CNN3 protein suppressed the invasive ability of gastric cancer cells. The highly invasive MKN-28 gastric cancer cells were more resistant to doxorubicin than the noninvasive MKN-45 cells; however, knockdown of CNN3 expression in MKN-28 cells resensitized them to doxorubicin treatment. Taken together, our results suggest that CNN3 plays a key role in invasiveness and doxorubicin resistance in gastric cancer cells.
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spelling pubmed-63980292019-03-25 Calponin 3 Regulates Cell Invasion and Doxorubicin Resistance in Gastric Cancer Hong, Keun-Seok Kim, Hyemin Kim, Seon-Hee Kim, Minju Yoo, Jiyun Gastroenterol Res Pract Research Article Calponin 3 (CNN3) is an F-actin-binding protein that regulates actin cytoskeletal rearrangement. However, the role of CNN3 in cancer cell invasion and resistance to chemotherapeutic agents has not yet been investigated. The present study was undertaken to investigate whether CNN3 influences cancer-related phenotypes in gastric cancer. We demonstrate that CNN3 contributes to cell invasion and resistance to doxorubicin in gastric cancer. CNN3 expression was markedly elevated in highly invasive cancer cell lines compared to less invasive or noninvasive cancer cell lines. Depletion of CNN3 protein suppressed the invasive ability of gastric cancer cells. The highly invasive MKN-28 gastric cancer cells were more resistant to doxorubicin than the noninvasive MKN-45 cells; however, knockdown of CNN3 expression in MKN-28 cells resensitized them to doxorubicin treatment. Taken together, our results suggest that CNN3 plays a key role in invasiveness and doxorubicin resistance in gastric cancer cells. Hindawi 2019-02-18 /pmc/articles/PMC6398029/ /pubmed/30911294 http://dx.doi.org/10.1155/2019/3024970 Text en Copyright © 2019 Keun-Seok Hong et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Hong, Keun-Seok
Kim, Hyemin
Kim, Seon-Hee
Kim, Minju
Yoo, Jiyun
Calponin 3 Regulates Cell Invasion and Doxorubicin Resistance in Gastric Cancer
title Calponin 3 Regulates Cell Invasion and Doxorubicin Resistance in Gastric Cancer
title_full Calponin 3 Regulates Cell Invasion and Doxorubicin Resistance in Gastric Cancer
title_fullStr Calponin 3 Regulates Cell Invasion and Doxorubicin Resistance in Gastric Cancer
title_full_unstemmed Calponin 3 Regulates Cell Invasion and Doxorubicin Resistance in Gastric Cancer
title_short Calponin 3 Regulates Cell Invasion and Doxorubicin Resistance in Gastric Cancer
title_sort calponin 3 regulates cell invasion and doxorubicin resistance in gastric cancer
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6398029/
https://www.ncbi.nlm.nih.gov/pubmed/30911294
http://dx.doi.org/10.1155/2019/3024970
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