Gcn5 histone acetyltransferase is present in the mitoplasts

In Saccharomyces cerevisiae the Lysine-acetyltransferase Gcn5 (KAT2) is part of the SAGA complex and is responsible for histone acetylation widely or at specific lysines. In this paper we report that GCN5 deletion differently affects the growth of two strains. The defective mitochondrial phenotype i...

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Autores principales: Montanari, Arianna, Leo, Manuela, De Luca, Veronica, Filetici, Patrizia, Francisci, Silvia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6398455/
https://www.ncbi.nlm.nih.gov/pubmed/30777878
http://dx.doi.org/10.1242/bio.041244
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author Montanari, Arianna
Leo, Manuela
De Luca, Veronica
Filetici, Patrizia
Francisci, Silvia
author_facet Montanari, Arianna
Leo, Manuela
De Luca, Veronica
Filetici, Patrizia
Francisci, Silvia
author_sort Montanari, Arianna
collection PubMed
description In Saccharomyces cerevisiae the Lysine-acetyltransferase Gcn5 (KAT2) is part of the SAGA complex and is responsible for histone acetylation widely or at specific lysines. In this paper we report that GCN5 deletion differently affects the growth of two strains. The defective mitochondrial phenotype is related to a marked decrease in mtDNA content, which also involves the deletion of specific regions of the molecule. We also show that in wild-type mitochondria the Gcn5 protein is present in the mitoplasts, suggesting a new mitochondrial function independent from the SAGA complex and possibly a new function for this protein connecting epigenetics and metabolism.
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spelling pubmed-63984552019-03-05 Gcn5 histone acetyltransferase is present in the mitoplasts Montanari, Arianna Leo, Manuela De Luca, Veronica Filetici, Patrizia Francisci, Silvia Biol Open Research Article In Saccharomyces cerevisiae the Lysine-acetyltransferase Gcn5 (KAT2) is part of the SAGA complex and is responsible for histone acetylation widely or at specific lysines. In this paper we report that GCN5 deletion differently affects the growth of two strains. The defective mitochondrial phenotype is related to a marked decrease in mtDNA content, which also involves the deletion of specific regions of the molecule. We also show that in wild-type mitochondria the Gcn5 protein is present in the mitoplasts, suggesting a new mitochondrial function independent from the SAGA complex and possibly a new function for this protein connecting epigenetics and metabolism. The Company of Biologists Ltd 2019-02-15 /pmc/articles/PMC6398455/ /pubmed/30777878 http://dx.doi.org/10.1242/bio.041244 Text en © 2019. Published by The Company of Biologists Ltd http://creativecommons.org/licenses/by/4.0This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.
spellingShingle Research Article
Montanari, Arianna
Leo, Manuela
De Luca, Veronica
Filetici, Patrizia
Francisci, Silvia
Gcn5 histone acetyltransferase is present in the mitoplasts
title Gcn5 histone acetyltransferase is present in the mitoplasts
title_full Gcn5 histone acetyltransferase is present in the mitoplasts
title_fullStr Gcn5 histone acetyltransferase is present in the mitoplasts
title_full_unstemmed Gcn5 histone acetyltransferase is present in the mitoplasts
title_short Gcn5 histone acetyltransferase is present in the mitoplasts
title_sort gcn5 histone acetyltransferase is present in the mitoplasts
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6398455/
https://www.ncbi.nlm.nih.gov/pubmed/30777878
http://dx.doi.org/10.1242/bio.041244
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