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ApoE-associated modulation of neuroprotection from Aβ-mediated neurodegeneration in transgenic Caenorhabditis elegans

Allele-specific distinctions in the human apolipoprotein E (APOE) locus represent the best-characterized genetic predictor of Alzheimer's disease (AD) risk. Expression of isoform APOEε2 is associated with reduced risk, while APOEε3 is neutral and APOEε4 carriers exhibit increased susceptibility...

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Detalles Bibliográficos
Autores principales:	Griffin, Edward F., Scopel, Samuel E., Stephen, Cayman A., Holzhauer, Adam C., Vaji, Madeline A., Tuckey, Ryan A., Berkowitz, Laura A., Caldwell, Kim A., Caldwell, Guy A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Company of Biologists Ltd 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6398492/ https://www.ncbi.nlm.nih.gov/pubmed/30683808 http://dx.doi.org/10.1242/dmm.037218

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