SOD1 activity threshold and TOR signalling modulate VAP(P58S) aggregation via reactive oxygen species-induced proteasomal degradation in a Drosophila model of amyotrophic lateral sclerosis

Familial amyotrophic lateral sclerosis (ALS) is an incurable, late-onset motor neuron disease, linked strongly to various causative genetic loci. ALS8 codes for a missense mutation, P56S, in VAMP-associated protein B (VAPB) that causes the protein to misfold and form cellular aggregates. Uncovering...

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Detalles Bibliográficos
Autores principales: Chaplot, Kriti, Pimpale, Lokesh, Ramalingam, Balaji, Deivasigamani, Senthilkumar, Kamat, Siddhesh S., Ratnaparkhi, Girish S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6398501/
https://www.ncbi.nlm.nih.gov/pubmed/30635270
http://dx.doi.org/10.1242/dmm.033803

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