mTORC1 activation decreases autophagy in aging and idiopathic pulmonary fibrosis and contributes to apoptosis resistance in IPF fibroblasts

Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, and usually lethal disease associated with aging. However, the molecular mechanisms of the aging process that contribute to the pathogenesis of IPF have not been elucidated. IPF is characterized by abundant foci of highly active fibrobla...

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Detalles Bibliográficos
Autores principales: Romero, Yair, Bueno, Marta, Ramirez, Remedios, Álvarez, Diana, Sembrat, John C., Goncharova, Elena A., Rojas, Mauricio, Selman, Moisés, Mora, Ana L., Pardo, Annie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6398527/
https://www.ncbi.nlm.nih.gov/pubmed/27566137
http://dx.doi.org/10.1111/acel.12514

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6398527/
https://www.ncbi.nlm.nih.gov/pubmed/27566137
http://dx.doi.org/10.1111/acel.12514

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