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Rac1 Activity Is Modulated by Huntingtin and Dysregulated in Models of Huntington’s Disease

BACKGROUND: Previous studies suggest that Huntingtin, the protein mutated in Huntington’s disease (HD), is required for actin based changes in cell morphology, and undergoes stimulus induced targeting to plasma membranes where it interacts with phospholipids involved in cell signaling. The small GTP...

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Detalles Bibliográficos
Autores principales:	Tousley, Adelaide, Iuliano, Maria, Weisman, Elizabeth, Sapp, Ellen, Zhang, Ningzhe, Vodicka, Petr, Alexander, Jonathan, Aviolat, Hubert, Gatune, Leah, Reeves, Patrick, Li, Xueyi, Khvorova, Anastasia, Ellerby, Lisa M., Aronin, Neil, DiFiglia, Marian, Kegel-Gleason, Kimberly B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	IOS Press 2019
Materias:	Research Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6398565/ https://www.ncbi.nlm.nih.gov/pubmed/30594931 http://dx.doi.org/10.3233/JHD-180311

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