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Analysis of Death and Survival Factors Associated with Childhood Bacterial Meningitis at a Reference Pediatric Hospital in Antananarivo, Madagascar

BACKGROUND: Bacterial meningitis (BM) remains a global public health problem and most cases and deaths occur in Sub-Saharan Africa and especially in children less than five years old, due to a variety of factors. This study was conducted to determine the principal factors associated with death and s...

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Autores principales: Mioramalala, Sedera Aurélien, Ramasy Razafindratovo, Rado Malalatiana, Rakotozanany, Ando, Miarimbola, Raharizo, Weldegebriel, Goitom, Mwenda, Jason M, Robinson, Annick Lalaina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6398577/
https://www.ncbi.nlm.nih.gov/pubmed/30843000
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author Mioramalala, Sedera Aurélien
Ramasy Razafindratovo, Rado Malalatiana
Rakotozanany, Ando
Miarimbola, Raharizo
Weldegebriel, Goitom
Mwenda, Jason M
Robinson, Annick Lalaina
author_facet Mioramalala, Sedera Aurélien
Ramasy Razafindratovo, Rado Malalatiana
Rakotozanany, Ando
Miarimbola, Raharizo
Weldegebriel, Goitom
Mwenda, Jason M
Robinson, Annick Lalaina
author_sort Mioramalala, Sedera Aurélien
collection PubMed
description BACKGROUND: Bacterial meningitis (BM) remains a global public health problem and most cases and deaths occur in Sub-Saharan Africa and especially in children less than five years old, due to a variety of factors. This study was conducted to determine the principal factors associated with death and survival of children due to BM in a typical African tertiary health facility. METHODS: A retrospective case-control study of children hospitalized for BM was conducted in the University Hospital of Tsaralalàna (CHUMET). All children aged 3 to 59 months hospitalized for bacterial meningitis and confirmed by bacteriology were included. The cases were children who died from BM, and the controls were the survivors. Data was analyzed using Stata 13. RESULTS: The factors associated with death were the number of siblings over 3 (14,48 [2,53 - 82,95]), overcrowding (9,31 [1,39 - 62,29]), time before hospitalization of more than five days (9,26 [1,36 – 62,92]), impaired consciousness (47,74 [6,24 - 364,96]), and meningococcal meningitis (36,68 [1,90 – 704,97]). CONCLUSION: These factors are mainly indicators of low socioeconomic status, clinical severity of signs and particularly virulent organisms. The early detection of patients at risk allows clinicians to give them appropriate care right from admission. Further studies are necessary especially, the evaluation of the emergency care provided.
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spelling pubmed-63985772019-03-04 Analysis of Death and Survival Factors Associated with Childhood Bacterial Meningitis at a Reference Pediatric Hospital in Antananarivo, Madagascar Mioramalala, Sedera Aurélien Ramasy Razafindratovo, Rado Malalatiana Rakotozanany, Ando Miarimbola, Raharizo Weldegebriel, Goitom Mwenda, Jason M Robinson, Annick Lalaina J Immunol Sci Article BACKGROUND: Bacterial meningitis (BM) remains a global public health problem and most cases and deaths occur in Sub-Saharan Africa and especially in children less than five years old, due to a variety of factors. This study was conducted to determine the principal factors associated with death and survival of children due to BM in a typical African tertiary health facility. METHODS: A retrospective case-control study of children hospitalized for BM was conducted in the University Hospital of Tsaralalàna (CHUMET). All children aged 3 to 59 months hospitalized for bacterial meningitis and confirmed by bacteriology were included. The cases were children who died from BM, and the controls were the survivors. Data was analyzed using Stata 13. RESULTS: The factors associated with death were the number of siblings over 3 (14,48 [2,53 - 82,95]), overcrowding (9,31 [1,39 - 62,29]), time before hospitalization of more than five days (9,26 [1,36 – 62,92]), impaired consciousness (47,74 [6,24 - 364,96]), and meningococcal meningitis (36,68 [1,90 – 704,97]). CONCLUSION: These factors are mainly indicators of low socioeconomic status, clinical severity of signs and particularly virulent organisms. The early detection of patients at risk allows clinicians to give them appropriate care right from admission. Further studies are necessary especially, the evaluation of the emergency care provided. 2018-07-02 /pmc/articles/PMC6398577/ /pubmed/30843000 Text en http://creativecommons.org/licenses/by/4.0/ This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Mioramalala, Sedera Aurélien
Ramasy Razafindratovo, Rado Malalatiana
Rakotozanany, Ando
Miarimbola, Raharizo
Weldegebriel, Goitom
Mwenda, Jason M
Robinson, Annick Lalaina
Analysis of Death and Survival Factors Associated with Childhood Bacterial Meningitis at a Reference Pediatric Hospital in Antananarivo, Madagascar
title Analysis of Death and Survival Factors Associated with Childhood Bacterial Meningitis at a Reference Pediatric Hospital in Antananarivo, Madagascar
title_full Analysis of Death and Survival Factors Associated with Childhood Bacterial Meningitis at a Reference Pediatric Hospital in Antananarivo, Madagascar
title_fullStr Analysis of Death and Survival Factors Associated with Childhood Bacterial Meningitis at a Reference Pediatric Hospital in Antananarivo, Madagascar
title_full_unstemmed Analysis of Death and Survival Factors Associated with Childhood Bacterial Meningitis at a Reference Pediatric Hospital in Antananarivo, Madagascar
title_short Analysis of Death and Survival Factors Associated with Childhood Bacterial Meningitis at a Reference Pediatric Hospital in Antananarivo, Madagascar
title_sort analysis of death and survival factors associated with childhood bacterial meningitis at a reference pediatric hospital in antananarivo, madagascar
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6398577/
https://www.ncbi.nlm.nih.gov/pubmed/30843000
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