Single cell analysis identifies CRLF2 rearrangements as both early and late events in Down syndrome and non-Down syndrome acute lymphoblastic leukaemia

Deregulated expression of the type I cytokine receptor, CRLF2, is observed in 5-15% of precursor B-cell acute lymphoblastic leukaemia (B-ALL). We have previously reported the genomic landscape of patients with CRLF2 rearrangements (CRLF2-r) using both whole genome and exome sequencing, which identif...

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Detalles Bibliográficos
Autores principales: Potter, N, Jones, L, Blair, H, Strehl, S, Harrison, CJ, Greaves, M, Kearney, L, Russell, LJ
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6398588/
https://www.ncbi.nlm.nih.gov/pubmed/30487598
http://dx.doi.org/10.1038/s41375-018-0297-4

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