Inhibiting the MCM8‐9 complex selectively sensitizes cancer cells to cisplatin and olaparib

MCM8 and MCM9 are paralogues of the MCM2‐7 eukaryotic DNA replication helicase proteins and play a crucial role in a homologous recombination‐mediated repair process to resolve replication stress by fork stalling. Thus, deficiency of MCM8‐9 sensitizes cells to replication stress caused, for example,...

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Detalles Bibliográficos
Autores principales: Morii, Issay, Iwabuchi, Yukiko, Mori, Sumiko, Suekuni, Masaki, Natsume, Toyoaki, Yoshida, Kazumasa, Sugimoto, Nozomi, Kanemaki, Masato T., Fujita, Masatoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6398883/
https://www.ncbi.nlm.nih.gov/pubmed/30648820
http://dx.doi.org/10.1111/cas.13941

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6398883/
https://www.ncbi.nlm.nih.gov/pubmed/30648820
http://dx.doi.org/10.1111/cas.13941

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