Differential regulation of CpG island methylation within divergent and unidirectional promoters in colorectal cancer

The silencing of tumor suppressor genes by promoter CpG island (CGI) methylation is an important cause of oncogenesis. Silencing of MLH1 and BRCA1, two examples of oncogenic events, results from promoter CGI methylation. Interestingly, both MLH1 and BRCA1 have a divergent promoter, from which anothe...

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Detalles Bibliográficos
Autores principales: Namba, Shinichi, Sato, Kazuhito, Kojima, Shinya, Ueno, Toshihide, Yamamoto, Yoko, Tanaka, Yosuke, Inoue, Satoshi, Nagae, Genta, Iinuma, Hisae, Hazama, Shoichi, Ishihara, Soichiro, Aburatani, Hiroyuki, Mano, Hiroyuki, Kawazu, Masahito
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6398885/
https://www.ncbi.nlm.nih.gov/pubmed/30637877
http://dx.doi.org/10.1111/cas.13937

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